Current understanding of the role of microRNAs in spinocerebellar ataxias [0.03%]
目前微小核糖核酸在脊髓小脑共济失调中作用的研究进展
Edyta Koscianska,Wlodzimierz J Krzyzosiak
Edyta Koscianska
The number of studies highlighting the role of microRNAs (miRNAs) in human physiology and diseases is growing, but many miRNA-driven regulatory mechanisms remain elusive. A proper understanding of the exact functions of individual miRNAs an...
Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia [0.03%]
单侧小脑发育不全患者在运动想象时小脑VI-VIIB半球的激活与运动执行不同
Christophe Habas,Mario Manto
Christophe Habas
We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt...
Case Reports
Cerebellum & ataxias. 2014 Aug 6:1:6. DOI:10.1186/2053-8871-1-6 2014
Bin Li,Jing-Ning Zhu,Jian-Jun Wang
Bin Li
Histaminergic afferent system of the cerebellum, having been considered as an essential component of the direct hypothalamocerebellar circuits, originates from the tuberomammillary nucleus in the hypothalamus. Unlike the mossy fibers and cl...
Jan Cendelin
Jan Cendelin
Ataxic mutant mice can be used to represent models of cerebellar degenerative disorders. They serve for investigation of cerebellar function, pathogenesis of degenerative processes as well as of therapeutic approaches. Lurcher, Hot-foot, Pu...
Functional contributions of glutamate transporters at the parallel fibre to Purkinje neuron synapse-relevance for the progression of cerebellar ataxia [0.03%]
谷氨酸转运蛋白在并行纤维到浦肯野神经元突触的功能贡献及其与小脑共济失调进展的相关性
Emmet M Power,Ruth M Empson
Emmet M Power
Background: Rapid uptake of glutamate by neuronal and glial glutamate transporters (EAATs, a family of excitatory amino acid transporters) is critical for shaping synaptic responses and for preventing excitotoxicity. Two ...
Whole-brain connectivity analysis and classification of spinocerebellar ataxia type 7 by functional MRI [0.03%]
基于功能磁共振成像的第七型脊小脑共济失调的全脑连接分析及分类研究
Carlos R Hernandez-Castillo,Víctor Galvez,Consuelo Morgado-Valle et al.
Carlos R Hernandez-Castillo et al.
Background: Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder characterized by degeneration of the motor and visual systems. Besides neural deterioration, these patients also show functional connectivity changes ...