New ionizable lipids reduce the lipid-to-mRNA ratio for base editing [0.03%]
新型可离子化脂质降低碱基编辑的脂质/mRNA比例
Shuliang Gao,Qiaobing Xu
Shuliang Gao
Rescue of dead MnO2 for stable electrolytic Zn-Mn redox-flow battery: a metric of mediated and catalytic kinetics [0.03%]
用于锌锰红ox电池的死MnO2的复活：介体和催化动力学的一个指标
Qi Wang,Wanhai Zhou,Yanyan Zhang et al.
Qi Wang et al.
The virtues of electrolytic MnO2 aqueous batteries are high theoretical energy density, affordability and safety. However, the continuous dead MnO2 and unstable Mn2+/MnO2 electrolysis pose challenges to the practical output energy and lifes...
Semimetal-triggered covalent interaction in Pt-based intermetallics for fuel-cell electrocatalysis [0.03%]
基于半金属的Pt基互化物燃料电催化剂中的共价作用机制研究
Han Cheng,Renjie Gui,Chen Chen et al.
Han Cheng et al.
Platinum-based intermetallic compounds (IMCs) play a vital role as electrocatalysts in a range of energy and environmental technologies, such as proton exchange membrane fuel cells. However, the synthesis of IMCs necessitates recombination ...
High-voltage aqueous zinc-ion batteries with conversion-type anode and modified electrolyte [0.03%]
具有转换型阳极和改性电解质的高压水系锌离子电池
Junnan Hao,Shi-Zhang Qiao
Junnan Hao
Identification of mitochondrial ATP synthase as the cellular target of Ru-polypyridyl- β-carboline complexes by affinity-based protein profiling [0.03%]
基于亲和性的蛋白质谱分析识别复合物Ru-polypyridyl- β-卡啉的线粒体ATP合酶细胞靶点
Wen-Jin Wang,Yu-Yi Ling,Yin Shi et al.
Wen-Jin Wang et al.
Ruthenium polypyridyl complexes are promising anticancer candidates, while their cellular targets have rarely been identified, which limits their clinical application. Herein, we design a series of Ru(II) polypyridyl complexes containing bi...
Two-dimensional superconducting MoSi2N4(MoN)4n homologous compounds [0.03%]
二维超导MoSi₂N₄(MoN)₄ₙ同分异构体化合物
Zhibo Liu,Lei Wang,Yi-Lun Hong et al.
Zhibo Liu et al.
The number and stacking order of layers are two important degrees of freedom that can modulate the properties of 2D van der Waals (vdW) materials. However, the layers' structures are essentially limited to the known layered 3D vdW materials...
Polyoxometalates: metallodrug agents for combating amyloid aggregation [0.03%]
多金属氧酸盐：对抗淀粉样蛋白聚集的金属药物分子
Mengmeng Ma,Zhenqi Liu,Huisi Zhao et al.
Mengmeng Ma et al.
Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects ∼50 million people globally. The accumulation of amyloid-β (Aβ) plaques, a predominant pathological feature of AD, plays a crucial role in AD pathogenesis. ...
An ATP-responsive metal-organic framework against periodontitis via synergistic ion-interference-mediated pyroptosis [0.03%]
一种抗牙周炎的ATP响应金属有机骨架通过协同离子干扰诱导焦亡反应
Qijing Yang,Xiaolin Sun,Qihang Ding et al.
Qijing Yang et al.
Periodontitis involves hyperactivated stromal cells that recruit immune cells, exacerbating inflammation. This study presents an ATP-responsive metal-organic framework (Mg/Zn-MOF) designed for periodontitis treatment, utilizing ion interfer...
Zhi Wang,Yuchen Wang,Chengkai Zhang et al.
Zhi Wang et al.
Despite the discovery of a series of fullerenes and a handful of noncarbon clusters with the typical topology of I h-C60, the smallest fullerene with a large degree of curvature, C20, and its other-element counterparts are difficult to isol...
Distinct SARS-CoV-2 populational immune backgrounds tolerate divergent RBD evolutionary preferences [0.03%]
不同的SARS-CoV-2人口免疫背景容许RBD进化偏好发生变化
Wentai Ma,Haoyi Fu,Fanchong Jian et al.
Wentai Ma et al.
Immune evasion is a pivotal force shaping the evolution of viruses. Nonetheless, the extent to which virus evolution varies among populations with diverse immune backgrounds remains an unsolved mystery. Prior to the widespread SARS-CoV-2 in...