The challenges of pedigree dog health: approaches to combating inherited disease [0.03%]
谱系狗的健康挑战：应对遗传疾病的方法
Lindsay L Farrell,Jeffrey J Schoenebeck,Pamela Wiener et al.
Lindsay L Farrell et al.
The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnostic DNA disease tests, the full...
Development and validation of a diagnostic test for Ridge allele copy number in Rhodesian Ridgeback dogs [0.03%]
Rhodesianridgedog 基因型诊断检测方法的建立与验证
Jennifer Turner Waldo,Kasandra Santana Diaz
Jennifer Turner Waldo
Background: The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from tho...
Stephanie Jw Shoop,Stephanie Marlow,David B Church et al.
Stephanie Jw Shoop et al.
Background: Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk ...
Non-synonymous genetic variation in exonic regions of canine Toll-like receptors [0.03%]
犬TLR外显子区域的非同义遗传变异
Anna Cuscó,Armand Sánchez,Laura Altet et al.
Anna Cuscó et al.
Background: Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) considered to be the primary sensors of pathogens in innate immunity. Genetic variants could be associated to differences in breed innate imm...
A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118G > A) in a referral population of German Shepherd dogs from the UK [0.03%]
英国德国牧羊犬转诊群体中与犬退行性脊髓病相关的超氧化物歧化酶1基因突变(SOD1:c.118G>A)流行率的回顾性调查研究
Angela L Holder,James A Price,Jamie P Adams et al.
Angela L Holder et al.
Background: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to o...
Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog [0.03%]
柯利王查理士玩赏犬之海绵状脊髓病的危险与保护因子及其外观特征的关系
Thomas J Mitchell,Susan P Knowler,Henny van den Berg et al.
Thomas J Mitchell et al.
Background: Syringomyelia (SM) is a painful neurological condition, prevalent in brachycephalic toy breeds including the Cavalier King Charles Spaniel (CKCS). In these breeds, SM is typically secondary to Chiari-like Malf...
Searching for "monogenic diabetes" in dogs using a candidate gene approach [0.03%]
在狗身上寻找“单基因糖尿病”采用候选基因的方法
Andrea D Short,Angela Holder,Simon Rothwell et al.
Andrea D Short et al.
Background: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenc...
Holding back the genes: limitations of research into canine behavioural genetics [0.03%]
管住基因：犬行为遗传学研究的局限性
Diane van Rooy,Elizabeth R Arnott,Jonathan B Early et al.
Diane van Rooy et al.
Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen in Dobermanns. While the identi...
An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs [0.03%]
边境牧羊犬成年期听力损失遗传规律分析
Sheila M Schmutz
Sheila M Schmutz
Background: During routine diagnostic BAER testing of dogs of various breeds for private owners at the Western College of Veterinary Medicine in Saskatoon, it became evident that some individual dogs developed hearing los...
Carys A Pugh,Barend M de C Bronsvoort,Ian G Handel et al.
Carys A Pugh et al.
This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer the investigator an opportunity t...