Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom [0.03%]
英国针对拉福尔病的大规模基因检测以消除迷你刚毛矮脚狗中的该疾病
Saija Ahonen,Ian Seath,Clare Rusbridge et al.
Saija Ahonen et al.
Background: Canine DNA-testing has become an important tool in purebred dog breeding and many breeders use genetic testing results when planning their breeding strategies. In addition, information obtained from testing of...
Assessing the relative importance of health and conformation traits in the cavalier king Charles spaniel [0.03%]
评估查爾斯王健康和體質性狀的相對重要性
Katrien Wijnrocx,Liesbeth François,Peter Goos et al.
Katrien Wijnrocx et al.
Background: The selection of a future breeding dog is a complicated task, in which disease characteristics and different traits have to be combined and weighed against one another. Truncation selection, that is the exclus...
Moving from information and collaboration to action: report from the 3rd International Dog Health Workshop, Paris in April 2017 [0.03%]
从信息和协作到行动：2017年4月巴黎第三届国际犬健康研讨会报告
Dan G O&#x;Neill,Sylvia F A Keijser,Åke Hedhammar et al.
Dan G O&#x;Neill et al.
Background: Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel cl...
Border Terriers under primary veterinary care in England: demography and disorders [0.03%]
英国英格兰接受初级兽医保健的边境梗犬的病患流行特征及疾病状况
Dan G O&#x;Neill,Elisabeth C Darwent,David B Church et al.
Dan G O&#x;Neill et al.
Background: The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers rec...
Rottweilers under primary veterinary care in the UK: demography, mortality and disorders [0.03%]
英国导盲犬的兽医护理：人口统计、死亡率和疾病分布
Dan G O&#x;Neill,Wee Yin Seah,David B Church et al.
Dan G O&#x;Neill et al.
Background: Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly reco...
An autosomal recessive mutation in SCL24A4 causing enamel hypoplasia in Samoyed and its relationship to breed-wide genetic diversity [0.03%]
一种新的着色不良相关等位基因(SLC24A5)引起的一种罕见的遗传性乳光牙本质综合征病例报告及其对萨摩耶犬种群遗传多样性的影响
Niels C Pedersen,Bonnie Shope,Hongwei Liu
Niels C Pedersen
Background: Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indic...
Melissa Simpson,Erin Searfoss,Sharon Albright et al.
Melissa Simpson et al.
Background: Studying cancer and other diseases poses a problem due to their protracted and multifactorial nature. Prospective studies are useful to investigate chronic disease processes since collection of lifestyle infor...
Lumbosacral stenosis in Labrador retriever military working dogs - an exomic exploratory study [0.03%]
拉布拉多寻回犬役用军犬腰骶狭窄的外显子组探索性研究
Meenakshi Mukherjee,Jeryl C Jones,Jianbo Yao
Meenakshi Mukherjee
Background: Canine lumbosacral stenosis is defined as narrowing of the caudal lumbar and/or sacral vertebral canal. A risk factor for neurologic problems in many large sized breeds, lumbosacral stenosis can also cause ear...
Single nucleotide polymorphisms and microsatellites in the canine glutathione S-transferase pi 1 (GSTP1) gene promoter [0.03%]
犬谷胱甘肽S-转移酶派1(GSTP1)基因启动子的单核苷酸多态性和微卫星序列变异
James Sacco,Sarah Mann,Keller Toral
James Sacco
Background: Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substr...
Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds [0.03%]
一项针对英国 Kennel Club 注册的192个犬种的大规模调查以估计各类疾病的患病率
B M Wiles,A M Llewellyn-Zaidi,K M Evans et al.
B M Wiles et al.
Background: Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empiric...