Generic and disease-specific quality of life among youth and young men with Hemophilia in Canada [0.03%]
加拿大青年血友病患者的生活质量研究
J St-Louis,D J Urajnik,F Ménard et al.
J St-Louis et al.
Background: This study was undertaken to explore the longitudinal patterns of health-related quality of life (HRQoL) among youth and young adults with Hemophilia A (HA) over a 3-year period. This report presents the basel...
Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and poor prognosis due to red blood cell transfusion-dependent anemia and thrombocytopenia [0.03%]
QUAZAR低危骨髓增生异常综合征（AZA-MDS-003）试验的设计与原理：在国际预后评分系统定义的输血依赖性贫血和血小板减少的不良风险较低的骨髓增生异常综合征患者中，评估口服阿扎胞苷联合最佳支持治疗对比安慰剂联合最佳支持治疗的有效性和安全性的一项随机III期研究
Guillermo Garcia-Manero,Antonio Almeida,Aristoteles Giagounidis et al.
Guillermo Garcia-Manero et al.
Background: CC-486 is an oral formulation of the epigenetic modifier azacitidine. In an expanded phase 1 trial, CC-486 demonstrated clinical and biological activity in patients with International Prognostic Scoring System...
Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation [0.03%]
2Gy全身照射后异基因造血干细胞移植小犬皮肤朗格汉斯细胞嵌合体的动态变化规律研究
Sabrina Peters,Christian Junghanss,Anne Knueppel et al.
Sabrina Peters et al.
Background: Langerhans cells (LC) are bone marrow-derived cells in the skin. The LC donor/recipient chimerism is assumed to influence the incidence and severity of graft-versus-host disease (GVHD) after hematopoietic stem...
Abibatou Sall,Awa Oumar Touré,Fatimata Bintou Sall et al.
Abibatou Sall et al.
Background: Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL is the most common type of leukemia in Western populatio...
Endothelial fibrinolytic response onto an evolving matrix of fibrin [0.03%]
纤溶系统在不断变化的纤维蛋白基质上的响应机制研究
O Castillo,H Rojas,Z Domínguez et al.
O Castillo et al.
Background: Fibrin provides a temporary matrix at the site of vascular injury. The aims of the present work were (1) to follow fibrin formation and lysis onto the surface of human dermal microvascular endothelial cells (H...
A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis [0.03%]
一例以远端肾小管酸中毒和双侧广泛肾结石表现为多重骨髓瘤的病例报告
Chathuranga Lakmal Fonseka,Sampath Rukshani Galappaththi,Jeewandarage Dhanushka Karunarathna et al.
Chathuranga Lakmal Fonseka et al.
Background: At the time of diagnosis, Multiple Myeloma is commonly associated with renal impairment. Renal tubular acidosis without overt renal insufficiency is an uncommon disease presentation of myeloma. Among tubular a...
Case Reports
BMC hematology. 2016 Mar 17:16:8. DOI:10.1186/s12878-016-0047-7 2016
Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study [0.03%]
铁达尔特与蔗糖铁注射液随机双盲安全性比较研究——初步研究报告
Martha L Louzada,Cyrus C Hsia,Fatimah Al-Ani et al.
Martha L Louzada et al.
Background: Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies c...
Hospitalization for pulmonary embolism associated with antecedent testosterone or estrogen therapy in patients found to have familial and acquired thrombophilia [0.03%]
与先前的睾酮或雌激素治疗以及获得性和遗传性血栓形成倾向相关的肺栓塞住院患者的临床病理研究
Marloe Prince,Charles J Glueck,Parth Shah et al.
Marloe Prince et al.
Background: In patients hospitalized over a 4 year period for pulmonary embolism (PE), we assessed relationships of testosterone (TT) and estrogen therapy (ET) anteceding PE in patients found to have familial-acquired thr...
The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate [0.03%]
氮氯苯磷酸盐诱导小鼠严重贫血及对胚胎型血红蛋白表达的影响
Hirotada Otsuka,Jiro Takito,Yasuo Endo et al.
Hirotada Otsuka et al.
Background: Mammalian erythropoiesis can be divided into two distinct types, primitive and definitive, in which new cells are derived from the yolk sac and hematopoietic stem cells, respectively. Primitive erythropoiesis ...
Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process [0.03%]
肝病和SLE相关过度脾功能亢进再探讨：现有证据支持其发病机制为主动而非被动过程
John M Gemery,Andrew R Forauer,Anne M Silas et al.
John M Gemery et al.
Background: Active and passive theories have been advanced to explain splenomegaly and cytopenias in liver disease. Dameshek proposed active downregulation of hematopoiesis. Doan proposed passive trapping of blood compone...