Senolytics and cell senescence: historical and evolutionary perspectives [0.03%]
senolytics和细胞衰老：历史与进化观点
Caleb E Finch
Caleb E Finch
Senolytics are a new class of anti-aging drugs developed to selectively kill 'senescent' cells that are considered harmful in normal aging. More than 20 drug trials are ongoing with diverse 'senolytic cocktails'. This commentary on recent r...
Nausea, vomiting and conflict in pregnancy: The adaptive significance of Growth-Differentiation Factor 15 [0.03%]
妊娠期间的恶心、呕吐和冲突：生长分化因子15的意义
Bernard J Crespi
Bernard J Crespi
Nausea and vomiting in pregnancy (NVP) is heritable, common and aversive, and its extreme, hyperemesis gravidarum (HG), can be highly deleterious to the mother and fetus. Recent influential studies have demonstrated that HG is caused predom...
Introduction to the special issue: evolutionary and biopsychosocial perspectives on sickness communication [0.03%]
本期专刊简介：疾病传播的进化与生物心理社会学视角
Eric C Shattuck,Chloe C Boyle
Eric C Shattuck
Here, we introduce the EMPH special issue on Evolutionary and Biopsychosocial Perspectives on Sickness Communication. This Commentary provides an overview of each article and places them in the wider context of sickness as a social phenomen...
A multi-million-year natural experiment: Comparative genomics on a massive scale and its implications for human health [0.03%]
一项千万年自然实验：大规模比较基因组学及对人类健康的意义
Iker Rivas-González,Jenny Tung
Iker Rivas-González
Improving the diversity and quality of genome assemblies for non-human mammals has been a long-standing goal of comparative genomics. The last year saw substantial progress towards this goal, including the release of genome alignments for 2...
Bethany L P Gilbert,Sharon E Kessler
Bethany L P Gilbert
Life history theory indicates that individuals/species with a slow pace of life invest more in acquired than innate immunity. Factors that decrease the pace of life and predict greater investment in acquired immunity include increased nutri...
Reconsidering the developmental origins of adult disease paradigm: The 'metabolic coordination of childbirth' hypothesis [0.03%]
重新考虑成人疾病的发育起源范式：“生育的代谢调控”假说
Jonathan C K Wells,Gernot Desoye,David A Leon
Jonathan C K Wells
In uncomplicated pregnancies, birthweight is inversely associated with adult non-communicable disease (NCD) risk. One proposed mechanism is maternal malnutrition during pregnancy. Another explanation is that shared genes link birthweight wi...
Evolutionary and empirical perspectives on 'demand' breastfeeding: The baby in the driver's seat or the back seat? [0.03%]
从进化和经验的角度看“按需”哺乳：婴儿是开车的人，还是坐在后座的人？
David P Tracer
David P Tracer
Background/objectives: The concept of 'demand' breastfeeding is central in public health. A key feature of the concept is that the infant is the locus of control in the breastfeeding process; when the breast is demanded b...
Katherine R Amato,Priyanka Pradhan,Elizabeth K Mallott et al.
Katherine R Amato et al.
Mammalian pregnancy is characterized by a well-known suite of physiological changes that support fetal growth and development, thereby positively affecting both maternal and offspring fitness. However, mothers also experience trade-offs bet...
Sperm intrusion into the implantation-stage blastocyst and its potential biological significance [0.03%]
植入阶段胚胎中出现精子及其潜在生物学意义
Jayasree Sengupta,Thomas Kroneis,Amy M Boddy et al.
Jayasree Sengupta et al.
The human embryo derives from fusion of oocyte and sperm, undergoes growth and differentiation, resulting in a blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, allowing access from external inputs. Model...
The role of the behavioural immune system on covid-19 lockdown attitudes: The relationship with authoritarianism and collectivism [0.03%]
行为免疫系统在新冠肺炎隔离态度中的作用：与权威主义和集体主义的关系
Femke van Diepenbeek,Sharon E Kessler
Femke van Diepenbeek
Background and objectives: The behavioural immune system (BIS) is a motivational system that facilitates the avoidance of pathogens and is thought to have evolved as a less costly mechanism to combat infectious diseases c...