Clinical management of resistance evolution in a bacterial infection: A case study [0.03%]
细菌耐药演变的临床管理——一例研究
Robert J Woods,Andrew F Read
Robert J Woods
We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even t...
A clinical research pathway towards developing new insights into cardiomyopathy [0.03%]
心肌病新认识的临床研究途径
Daniel T Blumstein,Janet Buckner,Sajan Shah et al.
Daniel T Blumstein et al.
Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology [0.03%]
直径相反的疾病反映出了进化遗传中的权衡：来自精神病学、神经病学、风湿病学、肿瘤学和免疫学的证据
Bernard J Crespi,Matthew C Go
Bernard J Crespi
Tradeoffs centrally mediate the expression of human adaptations. We propose that tradeoffs also influence the prevalence and forms of human maladaptation manifest in disease. By this logic, increased risk for one set of diseases commonly en...
Near full-length HIV type 1M genomic sequences from Cameroon : Evidence of early diverging under-sampled lineages in the country [0.03%]
从喀麦隆获得人类免疫缺陷病毒1组M型近全长基因序列：该国早期产生且较少被采样的系群的证据
Marcel Tongo,Jeffrey R Dorfman,Melissa-Rose Abrahams et al.
Marcel Tongo et al.
Background: Cameroon is the country in which HIV-1 group M (HIV-1M) likely originated and is today a major hotspot of HIV-1M genetic diversity. It remains unclear, however, whether the highly divergent HIV-1M lineages fou...
Effects of local extrinsic mortality rate, crime and sex ratio on preventable death in Northern Ireland [0.03%]
北爱尔兰局部外生死亡率、犯罪和性别比例对预防性死亡的影响
Caroline Uggla,Ruth Mace
Caroline Uggla
Background and objectives: Individual investment in health varies greatly within populations and results in significant differences in the risk of preventable death. Life history theory predicts that individuals should al...
A genetic model of the effects of insecticide-treated bed nets on the evolution of insecticide-resistance [0.03%]
基于杀虫剂处理蚊帐的遗传模型及其对杀虫剂抗性进化的影响
Philip L G Birget,Jacob C Koella
Philip L G Birget
Background and objectives: The evolution of insecticide-resistance in malaria vectors is emerging as a serious challenge for the control of malaria. Modelling the spread of insecticide-resistance is an essential tool to u...
Alice M Clomegah,Stephen J Chapman
Alice M Clomegah
Horizontal Gene Transfer [0.03%]
水平基因转移
Alita R Burmeister
Alita R Burmeister
Val H Smith,Rebecca J Rubinstein,Serry Park et al.
Val H Smith et al.
Despite the impact of the human microbiome on health, an appreciation of microbial ecology is yet to be translated into mainstream medical training and practice. The human microbiota plays a role in the development of the immune system, in ...