Epidemiological transitions in human evolution and the richness of viruses, helminths, and protozoa [0.03%]
人类进化中的流行病学转型及其丰富的病毒、蠕虫和原生动物
Caroline R Amoroso,Charles L Nunn
Caroline R Amoroso
Background and objectives: In absolute terms, humans are extremely highly parasitized compared to other primates. This may reflect that humans are outliers in traits correlated with parasite richness: population density, ...
Hymenolepis diminuta-based helminth therapy in C3(1)-TAg mice does not alter breast tumor onset or progression [0.03%]
杯状膜壳绦虫感染不影响小鼠乳腺肿瘤的发病和进展
Scott Sauer,Dylan Beinart,Sade M B Finn et al.
Scott Sauer et al.
Background and objectives: An individual's risk of breast cancer is profoundly affected by evolutionary mismatch. Mismatches in Western society known to increase the risk of breast cancer include a sedentary lifestyle and...
Live fast, die young and sleep later: Life history strategy and human sleep behavior [0.03%]
活在当下，早死早超生：人生策略与人类睡眠行为的关系
Vahe Dishakjian,Daniel M T Fessler,Adam Maxwell Sparks
Vahe Dishakjian
Background and objectives: Life History Theory (LHT) describes trade-offs that organisms make with regard to three investment pathways: growth, maintenance and reproduction. In light of the reparative functions of sleep, ...
Sylwia Wrotek,Edmund K LeGrand,Artur Dzialuk et al.
Sylwia Wrotek et al.
Although fever is one of the main presenting symptoms of COVID-19 infection, little public attention has been given to fever as an evolved defense. Fever, the regulated increase in the body temperature, is part of the evolved systemic react...
Bernard Crespi,Joe Alcock
Bernard Crespi
Several recent studies have provided evidence that use of calcium channel blockers (CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus disease 2019 (COVID-19). Moreover, hypocalcemia (a reduced level of serum...
Between a hygiene rock and a hygienic hard place: Avoiding SARS-CoV-2 while needing environmental exposures for immunity [0.03%]
卫生与健康的夹缝生存：避免新型冠状病毒肺炎的同时又需要接触环境以增强免疫力
William Parker,Joshua T Sarafian,Sherryl A Broverman et al.
William Parker et al.
Suboptimal understanding of concepts related to hygiene by the general public, clinicians and researchers is a persistent problem in health and medicine. Although hygiene is necessary to slow or prevent deadly pandemics of infectious diseas...
High-altitude pulmonary edema [0.03%]
高原性肺水肿
Peter Woods,Joe Alcock
Peter Woods
Lay summary: High Altitude Pulmonary Edema (HAPE) is a potentially fatal disease of altitude, in which the lungs can become filled with fluid. In this article we explore the mechanisms causing this condition and how it can be viewed as a co...
Reconsidering LINE-1's role in cancer: does LINE-1 function as a reporter detecting early cancer-associated epigenetic signatures? [0.03%]
LINE-1在癌症中的作用再思考：LINE-1是否作为报告基因检测与早期癌症相关的表观遗传特征？
Maxfield M G Kelsey
Maxfield M G Kelsey
Long interspersed nuclear element-1 (LINE-1 or L1) is the only autonomously active retrotransposon in humans. While L1 has been implicated in several pathologies and the aging process, I present a model which challenges an understanding of ...
Too much of a good thing: Adaption to iron (II) intoxication in Escherichia coli [0.03%]
过犹不及——大肠杆菌对铁(II)中毒的适应性反应
Misty D Thomas,Akamu J Ewunkem,Sada Boyd et al.
Misty D Thomas et al.
Background: There has been an increased usage of metallic antimicrobial materials to control pathogenic and multi-drug resistant bacteria. Yet, there is a corresponding need to know if this usage leads to genetic adaptati...
Alma Solis,Charles L Nunn
Alma Solis
The global impact of the COVID-19 pandemic has disproportionately affected some communities and populations more than others. We propose that an interdisciplinary framework of 'One Health Disparities' advances understanding of the social an...