Michel Salzet
Michel Salzet
Multicellularity rests on a social contract: cells give up autonomy in exchange for shared resources, division of labour, and protection. Cancer is what happens when that contract collapses, and somatic evolution runs loose inside the body....
Alisha Khalil,Zaneta Marie Thayer,Luisa Maria Rivera
Alisha Khalil
Reproductive and metabolic hormone associations in adult Samoan males with and without obesity [0.03%]
肥胖与非肥胖萨摩亚成人男性生殖和代谢激素的相关性研究
Richard G Bribiescas,Kyle S Wiley,Amelia Sancilio et al.
Richard G Bribiescas et al.
Background: Obesity is a global health challenge prevalent in Samoa. However, the influence of obesity on adult male reproductive health in Samoa is poorly understood. ...
Life history enlightened therapies: cell cycle mapping to identify molecular targets to prevent hepatocellular carcinoma [0.03%]
生命史指导的治疗：细胞周期定位以识别分子靶点预防肝细胞癌
Anuraag Bukkuri,Janet McLaughlin,Andrew W Duncan et al.
Anuraag Bukkuri et al.
Background and objectives: Life history enlightened therapies (LHETs) were originally developed in cancer to combat therapeutic resistance by targeting pathological cell state transitions that enable evolutionary rescue a...
An evolutionary perspective on the use of betel nut and its effects on health outcomes [0.03%]
从进化角度审视槟榔的使用及其对健康结果的影响
Laura Perez,Katherine Wander,Kristin K Sznajder et al.
Laura Perez et al.
Background and objectives: The use of psychoactive substances appears to be a consistent behavior throughout human evolutionary history. In contemporary research, this is often attributed to the addictive properties of su...
The evolution of the Institute of Evolutionary Medicine at the University of Zurich (10-year anniversary) [0.03%]
苏黎世大学进化医学研究所的建立和发展（十周年纪念）
Abigail E Colby,Shania Lüthold,Nicole Bender et al.
Abigail E Colby et al.
Julianne R Stamer,Mario Apata Mamani,Bernardo Arriaza et al.
Julianne R Stamer et al.
Background and objectives: One Paleopathology is a novel concept in Paleopathology that extends the One Health paradigm into the past. A workshop at the University of Durham, UK, was held prior to the 2024 International S...
How and why does aging occur? Updating evolutionary theory to meet a new era of data [0.03%]
衰老是如何及为何发生的？更新进化理论以适应新时代的数据要求
C Jessica E Metcalf,Rozalyn M Anderson,Michael E Hochberg et al.
C Jessica E Metcalf et al.
Our ability to define the causes of aging could enable targeted interventions to extend healthspan. Classical evolutionary models based on individual age have provided critical insights into empirical trajectories of aging; however, gaps re...
Leveraging comparative phylogenetics for evolutionary medicine: applications to comparative oncology [0.03%]
利用比较谱系地理学进行医学演化研究及其在肿瘤学中的应用
Walker J Compton Mellon,Beckett Sterner,J Arvid Ågren et al.
Walker J Compton Mellon et al.
Comparative phylogenetics provides a wealth of computational tools to understand evolutionary processes and their outcomes. Advances in these methodologies have occurred in parallel with a surge in cross-species genomic and phenotypic data....
Divergent evolution of hepatocellular carcinoma genomes in chimpanzees and humans [0.03%]
黑猩猩和人类肝细胞癌基因组的分歧演化路径
Lin Kang,Katarzyna Michalak,Robin Varghese et al.
Lin Kang et al.
Background and objectives: Somatic mutation patterns in cancer remain largely unexplored outside humans, despite their significance for aging and oncogenesis. Chimpanzees (Pan troglodytes), sharing >98% genomic similarity...