Modeling the evolution of SARS-CoV-2 under non-pharmaceutical interventions and testing [0.03%]
在非药物干预和检测下的SARS-CoV-2进化模型
Yael Gurevich,Yoav Ram,Lilach Hadany
Yael Gurevich
Background and objectives: Social and behavioral non-pharmaceutical interventions (NPIs), such as mask-wearing, social distancing and travel restrictions, as well as diagnostic tests, have been broadly implemented in resp...
Greater chronic morbidity is associated with greater fatigue in six countries: A case of evolutionary mismatch? [0.03%]
六个国家慢性疾病负担更重与疲劳感更强有关：进化不匹配假说的一个例证？
Joshua M Schrock,Lawrence S Sugiyama,Nirmala Naidoo et al.
Joshua M Schrock et al.
Background and objectives: Human susceptibility to chronic non-communicable disease may be explained, in part, by mismatches between our evolved biology and contemporary environmental conditions. Disease-induced fatigue m...
Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution [0.03%]
SARS-CoV-2的突变率及其在实验进化过程中发生突变的现象
Massimo Amicone,Vítor Borges,Maria João Alves et al.
Massimo Amicone et al.
Background and objectives: To understand how organisms evolve, it is fundamental to study how mutations emerge and establish. Here, we estimated the rate of mutation accumulation of SARS-CoV-2 in vitro and investigated th...
Strength is negatively associated with depression and accounts for some of the sex difference: A replication and extension [0.03%]
力量与抑郁症负相关，并解释了性别差异：重复和扩展研究
Caroline B Smith,Tom Rosenström,Edward H Hagen
Caroline B Smith
Background: Depression occurs about twice as often in women as in men, a disparity that remains poorly understood. In a previous publication, Hagen and Rosenström predicted and found that grip strength, a highly sexually...
The evolution of the human healthcare system and implications for understanding our responses to COVID-19 [0.03%]
人类医疗保健系统的演变以及对理解我们对COVID-19的反应的影响
Sharon E Kessler,Robert Aunger
Sharon E Kessler
The COVID-19 pandemic has revealed an urgent need for a comprehensive, multidisciplinary understanding of how healthcare systems respond successfully to infectious pathogens-and how they fail. This study contributes a novel perspective that...
Roles for non-human primate-associated phage diversity in improving medicine and public health [0.03%]
非人灵长类动物相关噬菌体多样性在改善医学和公共健康中的作用
Jan F Gogarten
Jan F Gogarten
Mammals harbor trillions of microorganisms and understanding the ecological and evolutionary processes structuring these ecosystems may provide insights relevant to public health and medicine. Comparative studies with our closest living rel...
A growth area: A review of the value of clinical studies of child growth for palaeopathology [0.03%]
生长的研究：儿童生长临床研究在古病理学价值的述评
Sarah-Louise Decrausaz,Michelle E Cameron
Sarah-Louise Decrausaz
Studies of living children demonstrate that early life stress impacts linear growth outcomes. Stresses affecting linear growth may also impact later life health outcomes, including increased cardiometabolic disease risk. Palaeopathologists ...
Serial passage in an insect host indicates genetic stability of the human probiotic Escherichia coli Nissle 1917 [0.03%]
在昆虫宿主中的连续传代表明了人体益生菌大肠埃希氏菌Nissle 1917株的基因组稳定性
Nicolas C H Schröder,Ana Korša,Haleluya Wami et al.
Nicolas C H Schröder et al.
Background and objectives: The probiotic Escherichia coli strain Nissle 1917 (EcN) has been shown to effectively prevent and alleviate intestinal diseases. Despite the widespread medical application of EcN, we still lack ...
An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins [0.03%]
整合比较生理学和分子方法确定了海豚屏息能力的介体
Ashley M Blawas,Kathryn E Ware,Emma Schmaltz et al.
Ashley M Blawas et al.
Background and objectives: Ischemic events, such as ischemic heart disease and stroke, are the number one cause of death globally. Ischemia prevents blood, carrying essential nutrients and oxygen, from reaching tissues, l...
Optimal non-pharmaceutical intervention policy for Covid-19 epidemic via neuroevolution algorithm [0.03%]
基于神经进化算法的Covid-19流行病非药物干预最优策略
Arash Saeidpour,Pejman Rohani
Arash Saeidpour
Background: National responses to the Covid-19 pandemic varied markedly across countries, from business-as-usual to complete shutdowns. Policies aimed at disrupting the viral transmission cycle and preventing the overwhel...