Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation [0.03%]
雷贝拉唑通过调节SMAD3连接区磷酸化抑制纤维化
Linkai Li,Zhen Liang,Long Fan et al.
Linkai Li et al.
Epithelial-to-mesenchymal transition (EMT) and fibrosis are well-established biological outcomes of TGFβ-mediated signaling. Rabeprazole, a proton pump inhibitor (PPI), has been widely used as a first-line therapy for H. pylori infection. ...
Preventive effects of Dendrobium hybrid extract on free radical activity and melanoma cell proliferation by inducing apoptotic gene expression [0.03%]
石斛杂交品种提取物通过诱导凋亡基因表达降低自由基活性和黑色素瘤细胞增殖作用研究
Rungpailin Khonsap,Pilairath Meksangsee,Pichamon Kiatwuthinon et al.
Rungpailin Khonsap et al.
Dendrobium species are used in folk medicines due to their medicinal properties by acting as antioxidants and anticancer agents. Derived from parent plants used in dermatological treatments and cosmetics, Dendrobium Pearl Vera hybrid (DH) w...
ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cells [0.03%]
ERp46通过减轻脂毒性内质网应激来维持β细胞中的GLUT2表达和胰岛素分泌
Danling Chen,Xiaomin Chen,Yuan Tian et al.
Danling Chen et al.
Lipotoxicity-induced β-cell dysfunction is a critical contributor to the pathogenesis of type 2 diabetes mellitus. The aim of the present study was to investigate the role of endoplasmic reticulum-resident protein 46 (ERp46) in regulating ...
Silencing of lncRNA TFAP2A-AS1 attenuates the development of acute coronary syndrome by inhibiting TFAP2A expression [0.03%]
lncRNA TFAP2A-AS1沉默通过抑制TFAP2A表达抑制急性冠脉综合征发展
Shiwei Huang,Fanlu Guan,Fanhao Ye et al.
Shiwei Huang et al.
Acute coronary syndrome (ACS), the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide. The present study aimed to elucidate the preliminarily biological role and underlying mechanism of...
Association of PLA2G2A single nucleotide polymorphism and cardiometabolic diseases in an HIV-infected population [0.03%]
PLA2G2A单核苷酸多态性与HIV感染者的心代谢性疾病的相关性研究
Elvis Ngwa Ndonwi,Unati Nqebelele,Tandi Edith Matsha et al.
Elvis Ngwa Ndonwi et al.
While single nucleotide polymorphisms (SNPs) of the phospholipase A2 (PLA2) gene have been associated with cardiometabolic diseases (CMDs), such associations are yet to be demonstrated in a human immunodeficiency virus (HIV)-infected Africa...
Knockdown of ALOX15 alleviates acute coronary syndrome via the FGFR2/PI3K/AKT signaling pathway [0.03%]
ALOX15敲低通过FGFR2/PI3K/AKT信号通路缓解急性冠脉综合征
Hao Chen,Ning Zhu,Shiwei Huang et al.
Hao Chen et al.
Acute coronary syndrome (ACS) is a serious cardiovascular condition and a leading cause of mortality worldwide. Notably, 12/15-lipoxygenase (ALOX15) can be regulated by the long non-coding RNA ENST00000538705.1, thereby facilitating the pro...
Serotonin inhibits the influx of iron into cells by decreasing the expression of SLC11A2 in Caco-2 cells [0.03%]
五羟色胺通过降低Caco-2细胞中SLC11A2的表达来抑制铁向细胞内的流入
Yuta Sugino,Momoko Ameku,Norika Kawanishi et al.
Yuta Sugino et al.
Iron is an essential trace element for biological functions and its homeostasis is strictly regulated. Intestinal iron absorption primarily occurs in the duodenum, and the iron transporter solute carrier family 11 member 2 (SLC11A2; also kn...
Germ cell immunoprofile and KIT exon 17 mutation guide rectification of seminoma misclassified as epithelioid gastrointestinal stromal tumor: A case report [0.03%]
以生殖细胞免疫谱和KIT基因第11外显子突变检测纠正误诊的精原细胞瘤为上皮样胃肠道间质瘤：病例报告
Xinyi Zhang,Wei Yuan,Lei Ren et al.
Xinyi Zhang et al.
Seminoma, derived from germ cell neoplasia in situ, is the most common testicular germ cell neoplasm. Seminoma exhibits overlapping genetic mutations and immunohistochemical profiles with diverse tumors, substantially complicating diagnosis...
Case Reports
Biomedical reports. 2025 Nov 18;24(1):15. DOI:10.3892/br.2025.2088 2025
Janus kinase/signal transducer and activator of transcription pathway in schizophrenia (Review) [0.03%]
细胞内信号转导异常在精神分裂症发病机制中的作用及分子机制研究进展
Emmanouil Rizos,Christos Theleritis,James N Tsoporis et al.
Emmanouil Rizos et al.
Schizophrenia is a complex mental disorder that affects cognition, emotions and behaviour. Among the signaling pathways that show dysregulation in schizophrenia is the Janus kinase/signal transducer and activator of transcription (JAK/STAT)...
Hemp seed extract as a catalyst for cell proliferation via IGF-1 and growth hormone signaling: Increased natural regenerative potential of muscles [0.03%]
大麻籽提取物通过胰岛素样生长因子和生长激素信号促进细胞增殖：增强肌肉的自然再生潜能
Dong Young Kang,Yunkyeong Kwon,Hyo Tae Kim et al.
Dong Young Kang et al.
Hemp seeds provide a nutritious food source. They contain proteins and essential minerals such as phosphorus, potassium, magnesium, iron and zinc. These nutrients contribute to health benefits, including the support of cardiovascular health...