Evaluation of anionic polymer-coated siRNA lipoplexes prepared using a modified ethanol injection method [0.03%]
采用改良乙醇注入法制备阴离子聚合物包被的siRNA脂质复合物的评价研究
Kumi Kawano,Yoshiyuki Hattori
Kumi Kawano
Cationic liposomes are useful carriers for delivering small interfering RNA (siRNA). In our previous study, a simple and efficient modified ethanol injection (MEI) method was developed for the preparation of cationic siRNA lipoplexes. Howev...
Chengyi Liu,Shuang Zhang,Xiaoxian Yun et al.
Chengyi Liu et al.
Autophagy regulates the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and mediates BMSC-mediated bone remodeling under pathological conditions (such as osteoporosis and infectious bone defects). However, the regul...
Metabolic dysfunction-associated steatotic liver disease and metabolic abnormalities are associated with age and serum des-acyl ghrelin among apparently healthy females: Findings from a whole gastroenteropancreatic hormones survey with path analysis [0.03%]
代谢功能紊乱相关脂肪性肝病及代谢异常与健康女性的年龄和血清脱乙酰基胃泌素有关：一项关于胃肠胰激素调查（路径分析）的结果
Ching-Pin Lin,Hsin-Hung Chen,Wen-Chen Chuang et al.
Ching-Pin Lin et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition associated with metabolic disturbances, with high incidence in Asian regions. Numerous patients with MASLD, particularly females, are neither ob...
Postoperative prognostic factors for inability to walk at 6 weeks after fragility hip fracture surgery: A retrospective cohort study [0.03%]
脆弱性髋部骨折手术后6周不能行走的术后预后因素：一项回顾性队列研究
Thitirut Jongutchariya,Jittima Saengsuwan,Palanthorn Loomcharoen
Thitirut Jongutchariya
Fragility hip fractures are highly prevalent among the elderly and are associated with substantial morbidity, disability and increased mortality. The inability to regain ambulation after surgery substantially diminishes quality of life. The...
Integrated analysis of gut microbiota structure and metabolic function in patients with cirrhosis and refractory ascites [0.03%]
肝硬化合并难治性腹水患者肠道微生态结构和代谢功能的整合分析
Dianyan Chen,Sandu Liu,Ka Zhang et al.
Dianyan Chen et al.
Refractory ascites is a serious complication of decompensated cirrhosis, yet its intestinal microbial and metabolic characteristics remain incompletely understood. The present study combined 16S rRNA sequencing and gas chromatography-mass s...
Mitochondrial oxidative stress under hypoxia promotes gastric mucosal injury in portal hypertensive gastropathy [0.03%]
缺氧诱导的线粒体氧化应激促进门脉高压性胃病胃黏膜损伤
Jiajie Luo,Kaiduan Xie,Xingtong Ou et al.
Jiajie Luo et al.
Hypoxia, which represents a key pathological feature of gastric mucosal disorders, exacerbates mitochondrial oxidative stress through dysregulated cellular responses. However, the underlying mechanism of mitochondrial oxidative stress under...
Targeting mitochondrial oxidative stress: A novel therapeutic strategy for degenerative joint diseases (Review) [0.03%]
targeting线粒体氧化应激：退行性关节病的新型治疗策略(综述)
Yang Hou,Xiaolei Yang,Tianyi Zhao et al.
Yang Hou et al.
Degenerative joint diseases, such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA), cause pain and disability worldwide. Globally, OA affects >500 million individuals, IVDD affects 40-60% of adul...
Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome [0.03%]
多氯联苯153可改变肠道上皮细胞转录组
Hanna Ham,Prakrti Senthil,Stephanie C Tan et al.
Hanna Ham et al.
Polychlorinated biphenyl 153 (PCB153) is one of the most persistent environmental pollutants and abundant PCB congeners detected in human tissues, primarily acquired through dietary exposure. The intestinal epithelium therefore represents a...
Clinical application of the HALP score for predicting early neurological deterioration in older patients with acute cerebral infarction [0.03%]
HALP评分在老年急性脑梗死患者早期神经功能恶化的临床预测中的应用
Yong-Juan Lin,Ai-Bin Guo,Ming-Min Huang et al.
Yong-Juan Lin et al.
The present study aimed to examine the relationship between the composite biomarker hemoglobin, albumin, lymphocyte and platelet (HALP) score and early neurological deterioration (END) to identify patients predisposed to poor neurological o...
Cardiorenal safety and efficacy of angiotensin receptor-neprilysin inhibitors in heart failure across the ejection fraction spectrum: A meta-analysis and meta-regression of RCTs with 28,001 patients [0.03%]
射血分数谱系心力衰竭患者中血管紧张素受体-中性肽酶抑制剂的心肾安全性和疗效的meta分析和meta回归：涉及28001名患者的随机临床试验
Derren D C H Rampengan,Stevanus C Surya,Kevin C Tjandra et al.
Derren D C H Rampengan et al.
Angiotensin receptor-neprilysin inhibitors (ARNIs), including sacubitril/valsartan, exert blood pressure-lowering and organ-protective effects in patients with heart failure (HF). However, differences of these effects across HF phenotypes a...