VDAC1: The mitochondrial gatekeeper in the battle against hearing loss (Review) [0.03%]
VDAC1：对抗听力损失战役中的线粒体守门人（综述）
Zhong-Jia Ding,Yin Wang
Zhong-Jia Ding
The development of hearing loss is strongly associated with mitochondrial damage, particularly downstream of mitochondrial autophagy, which is a process that is coincidentally key for selectively removing damaged mitochondria. Voltage-depen...
Spermidine mitigates lipopolysaccharide-induced acute lung injury by enhancing autophagic flux [0.03%]
spermidine通过增强自噬流来缓解脂多糖诱导的急性肺损伤
Xin Zhang,Haining Lu,Xingsheng Xu
Xin Zhang
The primary pathological characteristics of acute lung injury (ALI), comprise the dysfunction of the endothelial barrier, primarily due to the death of pulmonary microvascular endothelial cells (PMVECs), with pyroptosis identified as the pr...
Short-term cognitive effects of anticholinergics in patients with neurogenic lower urinary tract dysfunction: A systematic review and meta-analysis [0.03%]
抗胆碱药对神经源性下尿路功能障碍患者短期认知影响的系统评价和 meta 分析
Hui Zhang,Yahong Wang
Hui Zhang
Neurogenic lower urinary tract dysfunction (NLUTD) is common in individuals with neurological disorders, leading to bladder overactivity and incontinence. Anticholinergic medications are frequently prescribed for symptom control, but concer...
Hsa_circ_0122913 suppresses the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells and is involved in the effects of icariin treatment via sponging miR-501-5p [0.03%]
CircRNA Hsa_circ_0122913通过海绵吸附miR-501-5p抑制骨髓间充质干细胞的增殖和成骨分化并参与淫羊藿素作用效应
Yeqing Wang,Minbo Liu,Changhua Liu et al.
Yeqing Wang et al.
Circular RNAs (circRNAs) play significant roles in several biological events. It has been revealed that hsa_circ_0122913 was upregulated in peripheral blood samples from patients with senile osteoporotic vertebral compression fracture. Ther...
A Cornelia de Lange syndrome NIPBL 5'-UTR mutation reduces cell proliferation in an in vitro model by downregulating RAD21 and β-catenin [0.03%]
NIPBL 5-UTRCornelia de Lange综合征突变通过下调RAD21和β-catenin降低体外模型细胞增殖
Qingqing Chen,Yonghua Chen,Chaochun Zou et al.
Qingqing Chen et al.
Cornelia de Lange Syndrome (CdLS) is a prevalent chromatinopathy, frequently caused by mutations in genes encoding cohesin complex components, with NIPBL being the most commonly affected. The present study aimed to investigate the effects o...
Prevalence and risk factors of obstructive sleep apnea in patients with unexplained dizziness: A real-world study [0.03%]
不明原因头晕患者阻塞性睡眠呼吸暂停的患病率及危险因素：一项真实世界研究
Norapat Limsirorat,Sitta Suntrawanichakul,Watchara Boonsawat et al.
Norapat Limsirorat et al.
Obstructive sleep apnea (OSA) is a globally prevalent sleep disorder linked to a wide range of systemic conditions, including cardiovascular and vestibular dysfunction. Dizziness is frequently encountered in clinical practice but underexplo...
Genome sequencing identifies uniparental isodisomy of chromosome 2p and a homozygous ABCG5 variant, enabling effective treatment of pediatric hypercholesterolemia after 13 years of therapeutic resistance: A case report [0.03%]
基因组测序识别出2号染色体短臂的单亲二体和ABCG5同源突变，使此前治疗抵抗长达13年的儿童高胆固醇血症得到有效治疗——病例报告
Hannah Kassaie,Chanatjit Cheawsamoot,Sunisa Kanchanasutthiyakorn et al.
Hannah Kassaie et al.
Sitosterolemia is a rare inherited disorder caused by mutations in ABCG5 or ABCG8 genes, resulting in abnormal accumulation of phytosterols. Clinically, it often resembles familial hypercholesterolemia (FH), which is much more common. The p...
Case Reports
Biomedical reports. 2025 Sep 17;23(5):178. DOI:10.3892/br.2025.2056 2025
Hyperthyroidism with reference to elevated serum FT3 and FT4 levels in patients with ischemic stroke [0.03%]
与血清FT3、FT4水平升高相关的卒中患者甲亢状态研究
Xianjing Zhang,Honghu Wu,Gaofeng Wang et al.
Xianjing Zhang et al.
Ischemic stroke and hyperthyroidism are common diseases and may be associated with each other. The aim of the present study was to investigate whether patients with hyperthyroidism are at risk of developing ischemic stroke, whilst also expl...
Exon 4 and intron 4 TP53 are both methylated in advanced-stage ovarian carcinomas [0.03%]
晚期卵巢癌中TP53的外显子4和内含子4均发生甲基化
Wiktor Szewczuk,Oksana Szewczuk,Krzysztof Czajkowski et al.
Wiktor Szewczuk et al.
Although intragenic CpG dinucleotides are conserved during evolution, they are also sensitive to methylation-dependent mechanisms. Methylation status of the TP53 introns 1, 3 and 4 have been analysed in stage III ovarian carcinoma (OC). In ...
Pro-angiogenic potential of the isoxazole derivative ISO-1 via α7-nAChRs activation in human endothelial cells [0.03%]
异噁唑衍生物ISO-1通过活化人血管内皮细胞α7烟碱型乙酰胆碱受体发挥促血管生成的潜力
Hilda Espinoza,Gabriel Vallejos,Michel Lapier et al.
Hilda Espinoza et al.
Angiogenesis is essential for tissue growth and repair, but its dysregulation is associated with various pathological conditions, such as cancer and ischemic disease. Non-neuronal α7-nicotinic acetylcholine receptors (α7-nAChRs) mediate a...