Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines [0.03%]
结核分枝杆菌通过重塑细胞因子和化学因子的异常表达逃逸感染的人破骨细胞并重构破骨细胞发育过程
Akiyoshi Hoshino,Sanshiro Hanada,Hiroyuki Yamada et al.
Akiyoshi Hoshino et al.
Spinal tuberculosis is a condition characterized by massive resorption of the spinal vertebrae due to the infection with Mycobacterium tuberculosis (Mtb). However, the pathogenesis of spinal tuberculosis has not been established because it ...
Role of the Listeria monocytogenes 2-Cys peroxiredoxin homologue in protection against oxidative and nitrosative stress and in virulence [0.03%]
双半胱氨酸型过氧化氢酶同源物在李氏菌抵抗氧化和亚硝化应激及致病性中的作用研究
Lone E Dons,Ahmed Mosa,Martin E Rottenberg et al.
Lone E Dons et al.
Peroxiredoxins contribute to protection of some bacteria against reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs). Listeria monocytogenes, a facultative intracellular bacterial pathogen, interacts with ROIs an...
Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour? [0.03%]
寄生虫及其在感染性休克中的作用——其免疫调节行为的新分支？
Marc P Hübner,Laura E Layland,Achim Hoerauf
Marc P Hübner
The prevalence of autoimmune and allergic disorders has dramatically increased in developed countries, and it is believed that our 'cleaner living' reduces exposure to certain microorganisms and leads to deviated and/or reduced regulation o...
Identification of a protective protein from stationary-phase exoproteome of Brucella abortus [0.03%]
从布鲁氏菌静止期胞外蛋白组鉴定出一个保护性蛋白
Shikha Jain,Subodh Kumar,Sudhir Dohre et al.
Shikha Jain et al.
Brucellosis is a worldwide zoonotic disease. No Brucella vaccine is available for use in humans, and existing animal vaccines have limitations. To search the putative vaccine candidates, we studied the exoproteome of Brucella abortus NCTC 1...
Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes [0.03%]
Cryptosporidium parvum与小鼠树突状细胞的相互作用导致了后者活化并携带寄生虫至肠系淋巴结
Gregorio Perez-Cordon,Guilin Yang,Boping Zhou et al.
Gregorio Perez-Cordon et al.
Dendritic cells (DCs) are the antigen-presenting cells capable of activating naïve T cells. Although CD4+ T cells are crucial for Cryptosporidium parvum clearance, little is known about the role of DCs in the immune response to this parasi...
Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders [0.03%]
精神和神经疾病中的易感基因富含I型单纯疱疹病毒/宿主互作组分基因
Chris J Carter
Chris J Carter
Herpes simplex virus 1 (HSV-1) can promote beta-amyloid deposition and tau phosphorylation, demyelination or cognitive deficits relevant to Alzheimer's disease or multiple sclerosis and to many neuropsychiatric disorders with which it has b...
Evaluation of YadC protein delivered by live attenuated Salmonella as a vaccine against plague [0.03%]
利用减毒活沙门氏菌递送耶尔森鼠疫杆菌YadC蛋白疫苗的评价研究
Wei Sun,Joseph Olinzock,Shifeng Wang et al.
Wei Sun et al.
Yersinia pestis YadB and YadC are two new outer membrane proteins related to its pathogenicity. Here, codon-optimized yadC, yadC810 (aa 32-551), or yadBC antigen genes delivered by live attenuated Salmonella strains are evaluated in mice fo...
The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation [0.03%]
结核分枝杆菌基因组中的RD1位点通过提高细胞质中钙离子水平和激活钙蛋白酶促进感染巨噬细胞分泌成熟IL-1α
Ruili Yang,Chen Xi,Dewamitta R Sita et al.
Ruili Yang et al.
Region of difference 1 (RD1) is a genomic locus in the Mycobacterium tuberculosis genome that has been shown to participate in the virulence of the bacterium, induction of cell death, and cytokine secretion in infected macrophages. In this ...
Pseudomonas aeruginosa-dependent upregulation of TLR2 influences host responses to a secondary Staphylococcus aureus infection [0.03%]
铜绿假单胞菌依赖的TLR2上调影响宿主对二次金黄色葡萄球菌感染的反应
Hee-Sung Shin,Jung-Hoon Lee,Se-Hwan Paek et al.
Hee-Sung Shin et al.
The clinical impact of polymicrobial infections has received increasing attention from the medical community. However, the potential effects of Pseudomonas aeruginosa infection on the development of host responses against Gram-positive bact...
Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm [0.03%]
流感嗜血杆菌和肺炎链球菌：以生物被膜的形式共存生长
Alexandra Tikhomirova,Stephen P Kidd
Alexandra Tikhomirova
Streptococcus pneumoniae and Haemophilus influenzae are both commensals of the human nasopharynx with an ability to migrate to other niches within the human body to cause various diseases of the upper respiratory tract such as pneumonia, ot...