Mass spectrometry-based proteomic analysis of Leishmania donovani soluble proteins in Indian clinical isolate [0.03%]
印度临床分离株中利什曼原虫可溶性蛋白质的质谱分析
Awanish Kumar,Pragya Misra,Brijesh Sisodia et al.
Awanish Kumar et al.
Leishmania donovani, a causative organism of visceral leishmaniasis (VL), is responsible for high mortality throughout the world. Due to the unsatisfactory treatment measures and increasing drug resistance, there has been an urgent need to ...
Identification and characterization of a novel inhibitor of alginate overproduction in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌藻酸盐过量产生抑制剂的鉴定与表征
T Ryan Withers,Yeshi Yin,Hongwei D Yu
T Ryan Withers
In this study, we performed whole-genome complementation using a PAO1-derived cosmid library, coupled with in vitro transposon mutagenesis, to identify gene locus PA1494 as a novel inhibitor of alginate overproduction in P. aeruginosa strai...
Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro: the Tromsø Staph and Skin Study [0.03%]
金黄色葡萄球菌鼻隔离株来自健康个体导致体外宿主细胞反应高度可变： Tromsø 金黄色葡萄球菌和皮肤研究
Fatemeh Askarian,Maria Sangvik,Anne-Merethe Hanssen et al.
Fatemeh Askarian et al.
Studies on Staphylococcus aureus populations colonizing the nasal cavity reveal that some bacterial strains are more common, while others are rarely found. This study included five isolates with the most common spa types and five isolates w...
Comparative Study
Pathogens and disease. 2014 Mar;70(2):158-66. DOI:10.1111/2049-632X.12099 2014
The presence of antibiotic-resistant nosocomial pathogens in endotracheal tube biofilms and corresponding surveillance cultures [0.03%]
导管生物被膜和相应的监控培养基中的耐药病原体的存在
Ilse Vandecandelaere,Nele Matthijs,Hans J Nelis et al.
Ilse Vandecandelaere et al.
Mechanically ventilated patients often develop ventilator-associated pneumonia (VAP). Soon after intubation, a mixed biofilm harboring microbial pathogens is formed on the endotracheal tube (ET). It is believed that this biofilm contributes...
A synthetic lymph node containing inactivated Treponema pallidum cells elicits strong, antigen-specific humoral and cellular immune responses in mice [0.03%]
一种合成淋巴结可在小鼠中引发强的特异于苍白密螺旋体灭活细胞的体液和细胞免疫应答
Lola V Stamm,Rebecca L Drapp
Lola V Stamm
The goal of this study was to investigate the use of a synthetic lymph node (SLN) for delivery of Treponema pallidum (Tp) antigens. Immune responses of C57BL/6 mice were analyzed at 4, 8, and 12 weeks after SLN implantation. Group 1 mice re...
Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis [0.03%]
结核分枝杆菌PE_PGRS33蛋白免疫调节功能的结构基础研究
Antonella Zumbo,Ivana Palucci,Alessandro Cascioferro et al.
Antonella Zumbo et al.
PE_PGRSs are a large family of proteins identified in Mycobacterium tuberculosis complex and in few other pathogenic mycobacteria. The PE domain of PE_PGRS33 mediates localization of the protein on the mycobacterial cell surface, where the ...
Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model [0.03%]
沙眼衣原体尿生殖道分离株的质粒缺陷通过小鼠模型降低其感染性和致病性
Ira M Sigar,Justin H Schripsema,Yibing Wang et al.
Ira M Sigar et al.
We hypothesized that the plasmid of urogenital isolates of Chlamydia trachomatis would modulate infectivity and virulence in a mouse model. To test this hypothesis, we infected female mice in the respiratory or urogenital tract with graded ...
Murine marginal zone B cells play a role in Vibrio cholerae LPS antibody responses [0.03%]
鼠边缘区B细胞在霍乱弧菌LPS抗体反应中发挥作用
William F Wade,R Glenn King,Cyrille Grandjean et al.
William F Wade et al.
The emergence of Vibrio cholerae (Vc) lipopolysaccharide (LPS) as a lead protective antigen for a cholera subunit vaccine has increased the interest in what type of B cell is best suited to generate anti-Vc LPS antibodies. A related questio...
Identification of immunoreactive proteins of Streptococcus agalactiae isolated from cultured tilapia in China [0.03%]
中国养殖罗非鱼中分离的无乳链球菌免疫反应蛋白鉴定
Guangjin Liu,Wei Zhang,Chengping Lu
Guangjin Liu
Streptococcus agalactiae (Group B streptococcus, GBS) is an important zoonotic pathogen that can cause lethal infections in humans and animals, including aquatic species. Immunoreactive proteins of the S. agalactiae strain, GD201008-001, is...
Alterations in TLRs as new molecular markers of congenital infections with Human cytomegalovirus? [0.03%]
tolls的改变作为先天性人巨细胞病毒感染的新分子标志物？
Wioletta Wujcicka,Jan Wilczyński,Dorota Nowakowska
Wioletta Wujcicka
Toll-like receptors (TLRs) play a crucial role in non-specific immunity against various infections. The most common intrauterine infection, caused by Human cytomegalovirus (HCMV), results in perinatal morbidity and mortality of primary infe...