Luísa C S Antunes,Paolo Visca,Kevin J Towner
Luísa C S Antunes
Acinetobacter baumannii is an opportunistic nosocomial pathogen and one of the six most important multidrug-resistant microorganisms in hospitals worldwide. This human pathogen is responsible for a vast array of infections, of which ventila...
Microbial cell surface proteins and secreted metabolites involved in multispecies biofilms [0.03%]
多物种生物被膜相关的微生物细胞表面蛋白及分泌代谢产物
Liesbeth Demuyser,Mary Ann Jabra-Rizk,Patrick Van Dijck
Liesbeth Demuyser
A considerable number of infectious diseases involve multiple microbial species coexisting and interacting in a host. Only recently however the impact of these polymicrobial diseases has been appreciated and investigated. Often, the causati...
Activation of NADPH oxidase is essential, but not sufficient, in controlling intracellular multiplication of Burkholderia pseudomallei in primary human monocytes [0.03%]
NADPH氧化酶的激活对控制Burkholderia pseudomallei在原代人单核细胞内的增殖是必不可少但尚不充分的
Chanthiwa Wikraiphat,Matsayapan Pudla,Pankaj Baral et al.
Chanthiwa Wikraiphat et al.
Burkholderia pseudomallei is a Gram-negative intracellular bacterium and the causative agent of melioidosis. Innate immune mechanisms against this pathogen, which might contribute to outcomes of melioidosis, are little known. We demonstrate...
Infectivity of urogenital Chlamydia trachomatis plasmid-deficient, CT135-null, and double-deficient strains in female mice [0.03%]
无质粒、CT135基因敲除及双重缺失的沙眼衣原体尿道生殖型菌株在雌性小鼠中的感染性研究
Gail L Sturdevant,Bing Zhou,John H Carlson et al.
Gail L Sturdevant et al.
Chlamydia trachomatis is the most common cause of human bacterial sexually transmitted infections and is the world's leading cause of infectious preventable blindness. The chlamydial 7.5-kb plasmid and chromosomal gene CT135 have been shown...
Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms [0.03%]
羟基自由基在环丙沙星对抗铜绿假单胞菌生物被膜的杀菌活性中的作用
Peter Ø Jensen,Alejandra Briales,Rikke P Brochmann et al.
Peter Ø Jensen et al.
Antibiotic-tolerant, biofilm-forming Pseudomonas aeruginosa has long been recognized as a major cause of chronic lung infections of cystic fibrosis patients. The mechanisms involved in the activity of antibiotics on biofilm are not complete...
Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity [0.03%]
游离膜蛋白C保守结构域C10在伯氏疏螺旋体感染和传播中的作用研究
Christopher G Earnhart,DeLacy V L Rhodes,Alexis A Smith et al.
Christopher G Earnhart et al.
OspC is produced by all species of the Borrelia burgdorferi sensu lato complex and is required for infectivity in mammals. To test the hypothesis that the conserved C-terminal motif (C10) of OspC is required for function in vivo, a mutant B...
Philip S Stewart
Philip S Stewart
This article examines a likely basis of the tenacity of biofilm infections that has received relatively little attention: the resistance of biofilms to mechanical clearance. One way that a biofilm infection persists is by withstanding the f...
Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats [0.03%]
HIV转基因大鼠发生骨吸收功能障碍的机制研究:细胞因子信号传导抑制蛋白-1(SOCS-1)表达上调的作用
Mark K Lafferty,Lori Fantry,Joseph Bryant et al.
Mark K Lafferty et al.
Accelerated bone loss leading to osteopenia, osteoporosis, and bone fracture is a major health problem that is increasingly common in human immunodeficiency virus (HIV)-infected patients. The underlying pathogenesis is unclear but occurs in...
Comparison and characterization of granulocyte cell models for Anaplasma phagocytophilum infection [0.03%]
不同粒细胞模型感染伴胞嗜吞噬虫素菌的比较与表征研究
Kristen E Rennoll-Bankert,Sara H Sinclair,Marguerite A Lichay et al.
Kristen E Rennoll-Bankert et al.
Anaplasma phagocytophilum, an obligate intracellular bacterium, modifies functions of its in vivo host, the neutrophil. The challenges of using neutrophils ex vivo necessitate cell line models. However, cell line infections do not currently...
Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments [0.03%]
侵袭性粘液型变异株A群链球菌生长不良且易受到破坏DNA治疗的影响
Chuan Chiang-Ni,Po-Xing Zheng,Shuying Wang et al.
Chuan Chiang-Ni et al.
Hyaluronic acid capsule is one of the most important virulence factors of group A Streptococcus (GAS). Over-production of capsule has been thought to enhance GAS virulence during infections. However, although the increased of capsule expres...