Minimum information about a biofilm experiment (MIABiE): standards for reporting experiments and data on sessile microbial communities living at interfaces [0.03%]
有关黏膜实验的最少信息（MIABiE）：关于附着微生物群落实验和数据报告的标准
Anália Lourenço,Tom Coenye,Darla M Goeres et al.
Anália Lourenço et al.
The minimum information about a biofilm experiment (MIABiE) initiative has arisen from the need to find an adequate and scientifically sound way to control the quality of the documentation accompanying the public deposition of biofilm-relat...
Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity [0.03%]
毒-抗毒素系统：其在细菌持久性、生物膜形成和致病性中的作用
Yurong Wen,Ester Behiels,Bart Devreese
Yurong Wen
One of the most pertinent recent outcomes of molecular microbiology efforts to understand bacterial behavior is the discovery of a wide range of toxin-antitoxin (TA) systems that are tightly controlling bacterial persistence. While TA syste...
Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis [0.03%]
结核分枝杆菌菌落对抗微生物药物耐受性的表达
David F Ackart,Laurel Hascall-Dove,Silvia M Caceres et al.
David F Ackart et al.
There is an urgent need to improve methods used to screen antituberculosis drugs. An in vitro assay was developed to test drug treatment strategies that specifically target drug-tolerant Mycobacterium tuberculosis. The H37Rv strain of M. tu...
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules [0.03%]
由2-氨基咪唑衍生物逆转结核分枝杆菌表型耐药性研究
David F Ackart,Erick A Lindsey,Brendan K Podell et al.
David F Ackart et al.
The expression of phenotypic drug resistance or drug tolerance serves as a strategy for Mycobacterium tuberculosis to survive in vivo antimicrobial drug treatment; however, the mechanisms are poorly understood. Progress toward a more in dep...
Mycobacterium tuberculosis pellicles express unique proteins recognized by the host humoral response [0.03%]
结核分枝杆菌菌膜表达独特的由宿主体液免疫识别的蛋白质
Patrick W Kerns,David F Ackhart,Randall J Basaraba et al.
Patrick W Kerns et al.
Mycobacterium tuberculosis (MTB) causes both acute and chronic infections in humans characterized by tolerance to antibiotics and reactivation to cause secondary tuberculosis. These characteristics have led to renewed interest in the in vit...
Anti-biofilm agents: recent breakthrough against multi-drug resistant Staphylococcus aureus [0.03%]
抗生物膜制剂：对抗多重耐药金黄色葡萄球菌的最新进展
Pooi Y Chung,Yien S Toh
Pooi Y Chung
Staphylococcus aureus is a Gram-positive pathogen that causes potentially life-threatening nosocomial- and community-acquired infections, such as osteomyelitis and endocarditis. Staphylococcus aureus has the ability to form multicellular, s...
Development of novel mechanisms for housing, handling, and remote monitoring of common marmosets at animal biosafety level 3 [0.03%]
适用于三级动物生物安全实验室的常见狨猴饲养、操作及远程监控的新设备研发
Diana S Powell,Reagan C Walker,Dennis T Heflin et al.
Diana S Powell et al.
The use of common marmosets as an alternative non-human primate model for infectious disease research using BSL-3 viruses such as Rift Valley fever virus (RVFV) presents unique challenges with respect to housing, handling, and safety. Subje...
Transcriptional profiling of recall responses to Francisella live vaccine strain [0.03%]
弗朗西斯菌活疫苗株的回忆反应转录谱分析
Chrysanthi Paranavitana,Luis DaSilva,Antoaneta Vladimirova et al.
Chrysanthi Paranavitana et al.
Global gene expression profile changes were monitored in human peripheral blood mononuclear cells (PBMCs) after challenge with the live vaccine strain (LVS) of Francisella tularensis. Because these PBMCs were from individuals previously imm...
Efficient inactivation of Burkholderia pseudomallei or Francisella tularensis in infected cells for safe removal from biosafety level 3 containment laboratories [0.03%]
快速有效灭活伯克霍尔德菌或弗朗西斯氏菌感染细胞以便从三级生物安全实验室转移出来的方法
Felicia D Emery,Jennifer M Stabenow,Mark A Miller
Felicia D Emery
Working with infectious agents that require BSL-3 level containment agents offers many challenges for researchers. BSL-3 containment laboratories are usually not equipped with expensive specialty equipment that is needed for studies such as...
The use of Nanotrap particles for biodefense and emerging infectious disease diagnostics [0.03%]
纳米捕获颗粒在生物防御和新兴传染病诊断中的应用
Nazly Shafagati,Alexis Patanarut,Alessandra Luchini et al.
Nazly Shafagati et al.
Detection of early infectious disease may be challenging due to the low copy number of organisms present. To overcome this limitation and rapidly measure low concentrations of the pathogen, we developed a novel technology: Nanotrap particle...