Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia [0.03%]
缺氧诱导因子1α在肺炎链球菌感染宿主防御中的作用
Liza Pereverzeva,Natasja A Otto,Hessel Peters-Sengers et al.
Liza Pereverzeva et al.
Hypoxia-inducible factor (HIF)1α is a transcription factor involved in cellular metabolism and regulation of immune cell effector functions. Here, we studied the role of HIF1α in myeloid cells during pneumonia caused by the major causativ...
Clinical strains of Mycobacterium tuberculosis exhibit differential lipid metabolism-associated transcriptome changes in in vitro cholesterol and infection models [0.03%]
临床分离的结核分枝杆菌在体外胆固醇和感染模型中表现出与脂质代谢有关的转录组变化差异
Kynesha Moopanar,Asanda Nomfundo Graduate Nyide,Sibusiso Senzani et al.
Kynesha Moopanar et al.
Many studies have identified host-derived lipids, characterised by the abundance of cholesterol, as a major source of carbon nutrition for Mycobacterium tuberculosis during infection. Members of the Mycobacterium tuberculosis complex are bi...
Strategies for change: thriving as an individual with a disabilty in STEMM [0.03%]
改变策略：作为STEMM领域中残障个体的繁荣发展之道
Amber Crabtree,Kit Neikirk,Andrea Marshall et al.
Amber Crabtree et al.
Disability remains an underacknowledged and underdiscussed topic in science, technology, engineering, mathematics, and medicine (STEMM). Social stigma and fear of negative outcomes have resulted in a consistent lack of disclosure. Disabilit...
Impact of nutrients on the function of the chlamydial Rsb partner switching mechanism [0.03%]
营养物质对衣原体Rsb伙伴切换机制功能的影响
Shiomi Kuwabara,Evan R Landers,Derek J Fisher
Shiomi Kuwabara
The obligate intracellular bacterial pathogen Chlamydia trachomatis is a leading cause of sexually transmitted infections and infectious blindness. Chlamydia undergo a biphasic developmental cycle alternating between the infectious elementa...
Chao Zhang,Deyi Li,Zhirong Meng et al.
Chao Zhang et al.
Malaria, a mosquito-borne infectious disease, is caused by the unicellular apicomplexan protozoa of the genus Plasmodium. For malaria parasite transmission, the essential sexual stage includes production of gametocytes through gametocytogen...
Proteomic profiling of extracellular vesicles derived from ARPE-19 cells challenged with Aspergillus flavus and Candida albicans: application in fungal endophthalmitis [0.03%]
黄曲霉和白色念珠菌诱导的ARPE-19细胞来源的外泌体蛋白质组学研究及其在真菌性眼内炎的应用价值
Jaishree Gandhi,Joveeta Joseph
Jaishree Gandhi
Extracellular vesicles (EVs) are nano-sized-particles that play an important role in cellular cross-talk. The aim of this study was to understand the proteomic cargo of EVs, released by Retinal Pigment Epithelial (RPE) cells challenged with...
Trichinella spiralis-derived extracellular vesicles induce a protective immunity against larval challenge in mice [0.03%]
猪旋毛虫源外泌体诱导小鼠抵抗线虫感染的保护性免疫反应
Dalia S Ashour,Fatma M Kh Ibrahim,Amira M Elshamy et al.
Dalia S Ashour et al.
Human trichinellosis is a serious disease with no effective treatment till now. Recently, the protective immunity induced by parasite-derived extracellular vesicles (EVs) are studied for some parasites such as Echinostoma caproni. The curre...
Phages, anti-CRISPR proteins, and drug-resistant bacteria: what do we know about this triad? [0.03%]
噬菌体、抗CRISPR蛋白和耐药菌之间有何关联？
Andres Ceballos-Garzon,Angela B Muñoz,Juan D Plata et al.
Andres Ceballos-Garzon et al.
Phages are viruses that infect bacteria, relying on their genetic machinery to replicate. To survive the constant attack of phages, bacteria have developed diverse defense strategies to act against them. Nevertheless, phages rapidly co-evol...
Adjuvants to increase immunogenicity of SARS-CoV-2 RBD and support maternal-fetal transference of antibodies in mice [0.03%]
增强SARS-CoV-2 RBD免疫原性的佐剂及支持小鼠母胎抗体转移的佐剂研究
Gabrielle Gimenes Lima,Amanda Izeli Portilho,Elizabeth De Gaspari
Gabrielle Gimenes Lima
Adjuvants are important components of vaccines, increasing immunogenicity and modulating the immune response. SARS-CoV-2 vaccines are still being developed in order to improve worldwide access to immunization. Specific populations should be...