HspX vaccination and role in virulence in the guinea pig model of tuberculosis [0.03%]
热休克蛋白HspX的疫苗作用及在感染模型中的致病性研究
Agatha E Wieczorek,Jolynn L Troudt,Phillip Knabenbauer et al.
Agatha E Wieczorek et al.
Mycobacterium tuberculosis (Mtb) currently infects billions of people; many of whom are latently infection and at risk for reactivation. Mycobacterium bovis Bacille Calmette-Guerin (BCG) while approved as a vaccine, is unable to prevent rea...
Biocontainment laboratory risk assessment: perspectives and considerations [0.03%]
生物安全实验室风险评估：视角和考量因素
Amy Patterson,Kelly Fennington,Ryan Bayha et al.
Amy Patterson et al.
The ability to respond to public health emergencies involving infectious diseases as well as our ability to adequately prepare for as yet unknown or unrecognized emerging infectious diseases requires suitable facilities within which scienti...
Shauna Milne-Price,Kerri L Miazgowicz,Vincent J Munster
Shauna Milne-Price
On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED-mail. Within a few days, the same virus was detected in a Qatari patient receiving intensive care in a Lo...
A personal history of research on microbial biofilms and biofilm infections [0.03%]
微生物生物膜及生物膜感染的研究历史
Niels Høiby
Niels Høiby
The observation of aggregated microorganisms surrounded by a self-produced matrix adhering to surfaces or located in tissues or secretions is as old as microbiology, with both Leeuwenhoek and Pasteur describing the phenomenon. In environmen...
Innate immunity is sufficient for the clearance of Chlamydia trachomatis from the female mouse genital tract [0.03%]
固有免疫足以清除雌性小鼠生殖道中的沙眼衣原体感染
Gail L Sturdevant,Harlan D Caldwell
Gail L Sturdevant
Chlamydia muridarum and Chlamydia trachomatis, mouse and human strains, respectively, have been used to study immunity in a murine model of female genital tract infection. Despite evidence that unique genes of these otherwise genomically si...
Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick [0.03%]
NIH/NIAID综合研究设施-弗雷德里克的系统机能组学在高后果病原体宿主反应表征中的应用
Jason Kindrachuk,Shane Falcinelli,Jiro Wada et al.
Jason Kindrachuk et al.
Currently, there is a paucity of information regarding the molecular pathogenesis for many high-consequence pathogens (HCPs) that pose threats to both national and international public health. In spite of this, investigations of the molecul...
Identification, immunogenicity, and cross-reactivity of type IV pilin and pilin-like proteins from Clostridium difficile [0.03%]
产气荚膜梭菌IV型菌毛蛋白和菌毛样蛋白的鉴定、免疫原性及交叉反应性研究
Grace A Maldarelli,Leon De Masi,Erik C von Rosenvinge et al.
Grace A Maldarelli et al.
The Gram-positive anaerobe Clostridium difficile is the major cause of nosocomial diarrhea; manifestations of infection include diarrhea, pseudomembranous colitis, and death. Genes for type IV pili, a bacterial nanofiber often involved in c...
Mapping complex traits using families of recombinant inbred strains: an overview and example of mapping susceptibility to Candida albicans induced illness phenotypes [0.03%]
利用重组近交系家族定位复杂性状的研究概述及白色念珠菌诱导的疾病表型易感位点的定位研究为例
Linda A Toth,Rita A Trammell,Robert W Williams
Linda A Toth
This overview and data-based example indicate how large families of recombinant inbred (RI) strains can be used to identify genetic loci and genes that underlie complex phenotypic differences among inbred mice. The RI approach requires no a...
Communication and computing technology in biocontainment laboratories using the NEIDL as a model [0.03%]
基于NEIDL的生物安全实验室内的通讯与计算技术
John McCall,Kath Hardcastle
John McCall
The National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, is a globally unique biocontainment research facility housing biosafety level 2 (BSL-2), BSL-3, and BSL-4 laboratories. Located in the BioSquare area at the ...
Temporal expression of agrB, cidA, and alsS in the early development of Staphylococcus aureus UAMS-1 biofilm formation and the structural role of extracellular DNA and carbohydrates [0.03%]
agrB、cidA和alsS在表皮葡萄球菌UAMS-1生物膜早期形成过程中的时间表达以及细菌DNA和多糖的结构作用分析
Rossella Grande,Laura Nistico,Karthik Sambanthamoorthy et al.
Rossella Grande et al.
Extracellular DNA (eDNA) is an important component of the extracellular polymeric substance matrix and is important in the establishment and persistence of Staphylococcus aureus UAMS-1 biofilms. The aim of the study was to determine the tem...