The genetic basis of plasmid tropism between Chlamydia trachomatis and Chlamydia muridarum [0.03%]
沙眼衣原体和鼠型衣原体质粒趋向性的遗传基础
Yibing Wang,Lesley T Cutcliffe,Rachel J Skilton et al.
Yibing Wang et al.
The development of genetic transformation technology for Chlamydia trachomatis using its endogenous plasmid has recently been described. Chlamydia muridarum cannot be transformed by the C. trachomatis plasmid, indicating a barrier between c...
A putative de-N-acetylase of the PIG-L superfamily affects fluoroquinolone tolerance in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中的一种假定的去乙酰化酶影响其对氟喹诺酮类药物的耐受性
Veerle Liebens,Valerie Defraine,Annelies Van der Leyden et al.
Veerle Liebens et al.
A major cause of treatment failure of infections caused by Pseudomonas aeruginosa is the presence of antibiotic-insensitive persister cells. The mechanism of persister formation in P. aeruginosa is largely unknown, and so far, only few gene...
Oral immunization with recombinant Lactococcus lactis delivering a multi-epitope antigen CTB-UE attenuates Helicobacter pylori infection in mice [0.03%]
用重组乳酸乳球菌递送CTB-UE多表位抗原进行口服免疫可减轻小鼠的幽门螺杆菌感染
Xinyang Li,Yingying Xing,Le Guo et al.
Xinyang Li et al.
Urease is an essential virulence factor and colonization factor for Helicobacter pylori (H. pylori) and is considered as an excellent vaccine candidate antigen. However, conventional technologies for preparing an injectable vaccine require ...
Genetic control of weight loss during pneumonic Burkholderia pseudomallei infection [0.03%]
基因控制肺炎贝氏菌感染期间的体重减轻
Felicia D Emery,Jyothi Parvathareddy,Ashutosh K Pandey et al.
Felicia D Emery et al.
Burkholderia pseudomallei (Bp) is the causal agent of a high-morbidity/mortality disease syndrome known as melioidosis. This syndrome can range from acute fulminate disease to chronic, local, and disseminated infections that are often diffi...
The NIAID Integrated Research Facility at Frederick, Maryland: a unique international resource to facilitate medical countermeasure development for BSL-4 pathogens [0.03%]
马里兰州弗雷德里克的国家过敏和传染病研究所综合研究中心：开发四级生物安全实验室病原体医疗反措施的独特国际资源
Peter B Jahrling,Lauren Keith,Marisa St Claire et al.
Peter B Jahrling et al.
Scientists at the National Institute of Allergy and Infectious Diseases Integrated Research Facility at Fort Detrick, Frederick, Maryland, coordinate and facilitate preclinical research on infectious diseases to develop medical countermeasu...
The deletion of TonB-dependent receptor genes is part of the genome reduction process that occurs during adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung [0.03%]
铜绿假单胞菌适应囊性纤维化患者肺部过程中基因组精简作用导致了TonB依赖型受体基因的丢失事件
Jozef Dingemans,Lumeng Ye,Falk Hildebrand et al.
Jozef Dingemans et al.
Chronic Pseudomonas aeruginosa infections are the main cause of morbidity among patients with cystic fibrosis (CF) due to persistent lung inflammation caused by interaction between this bacterium and the immune system. Longitudinal studies ...
Promising results of cranberry in the prevention of oral Candida biofilms [0.03%]
蔓越莓在预防口腔念珠菌生物膜形成中的作用研究取得进展
Marion Girardot,Amandine Guerineau,Leslie Boudesocque et al.
Marion Girardot et al.
In the context of dental caries prevention by natural foodstuff sources, antifungal and antibiofilm activities of dry commercial extracts of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and ...
High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation [0.03%]
高内涵表型筛选鉴定假丝酵母菌生物被膜形成和菌丝生长的抑制剂
Christopher G Pierce,Stephen P Saville,Jose L Lopez-Ribot
Christopher G Pierce
Candida species represent the main cause of opportunistic fungal infections worldwide, and Candida albicans remains the most common etiological agent of candidiasis, now the third to fourth most common nosocomial infection. These infections...
Increased production of gliotoxin is related to the formation of biofilm by Aspergillus fumigatus: an immunological approach [0.03%]
曲霉菌通过免疫学方法增加gliotoxin的生成与生物被膜的形成有关
Francesca Bugli,Francesco Paroni Sterbini,Margherita Cacaci et al.
Francesca Bugli et al.
Gliotoxin (GT) belongs to the epipolythiodioxopiperazine class of toxins secreted from certain fungi including Aspergillus fumigatus, which is the most prolific producer of this secondary metabolite. Recently, enhanced amounts of GT were fo...
Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence [0.03%]
FPI蛋白IglE的脂化对福氏耐利因子沙门氏菌新型亚种novicida的胞内复制及毒力的贡献作用
Jesse Q Nguyen,Ryan P Gilley,Xhavit Zogaj et al.
Jesse Q Nguyen et al.
Francisella tularensis is a Gram-negative bacterium responsible for the human disease tularemia. The Francisella pathogenicity island (FPI) encodes a secretion system related to type VI secretion systems (T6SS) which allows F. tularensis to...