Chlamydia pneumoniae infection of lungs and macrophages indirectly stimulates the phenotypic conversion of smooth muscle cells and mesenchymal stem cells: potential roles in vascular calcification and fibrosis [0.03%]
肺炎衣原体感染通过巨噬细胞和肺脏间接刺激平滑肌细胞和间充质干细胞表型转换的潜在作用：在血管钙化和纤维化中的可能角色
Sarah Cabbage,Nicholas Ieronimakis,Michael Preusch et al.
Sarah Cabbage et al.
Two hallmarks of advanced atherosclerosis are calcification and fibrosis. We hypothesized that Chlamydia pneumoniae infection may contribute to atherosclerosis by inducing the conversion of vascular smooth muscle cells to calcifying cells o...
In vivo imaging of bioluminescent Pseudomonas aeruginosa in an acute murine airway infection model [0.03%]
急性小鼠支气管感染模型中荧光假单胞菌的活体成像研究
Antje Munder,Florian Wölbeling,Jens Klockgether et al.
Antje Munder et al.
Non-invasive bioluminescence imaging allows the analysis of infectious diseases in small animal models. In this study, an acute airway infection of C3H/HeN mice with luxCDABE transformed Pseudomonas aeruginosa TBCF10839 and an isogenic tran...
LEAP-2, LL-37 and RNase7 in tonsillar tissue: downregulated expression in seasonal allergic rhinitis [0.03%]
扁桃体组织中的LEAP-2、LL-37和RNase7的表达在季节性过敏性鼻炎时下调
Jesper Bogefors,Anne Månsson Kvarnhammar,Camilla Rydberg Millrud et al.
Jesper Bogefors et al.
In the upper airway, the production of antimicrobial peptides (AMPs) protects against bacteria, viruses and fungi. Previous investigations have revealed downregulated expression of AMPs in different manifestations of allergic disease. In th...
Prior to Foxp3⁺ regulatory T-cell induction, interleukin-10-producing B cells expand after Helicobacter pylori infection [0.03%]
在Foxp3⁺调节性T细胞诱导之前，Helicobacter pylori感染后会产生产生IL-10的B细胞
Lumin Wei,Jingtong Wang,Yulan Liu
Lumin Wei
Regulatory T (Treg) cells play a critical role in Helicobacter pylori immune evasion and persistent infection. In addition to Treg cells, it is still unknown whether a newly defined B-cell subset, interleukin (IL)-10-producing B cells, is i...
Growth, motility and resistance to oxidative stress of the melioidosis pathogen Burkholderia pseudomallei are enhanced by epinephrine [0.03%]
肾上腺素可增强贝氏嗜肺军团菌的生长、运动性和抗氧化应激能力
Narin Intarak,Veerachat Muangsombut,Paiboon Vattanaviboon et al.
Narin Intarak et al.
Burkholderia pseudomallei causes melioidosis, a severe invasive disease endemic in South-East Asia and Northern Australia. Bacterial pathogens of several genera have been reported to be able to sense and respond to the stress-related catech...
Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa [0.03%]
体外模拟宿主及其微环境以研究铜绿假单胞菌的黏膜感染
Aurélie Crabbé,Maria A Ledesma,Cheryl A Nickerson
Aurélie Crabbé
Why is a healthy person protected from Pseudomonas aeruginosa infections, while individuals with cystic fibrosis or damaged epithelium are particularly susceptible to this opportunistic pathogen? To address this question, it is essential to...
Luwanika Mlera,Wessam Melik,Marshall E Bloom
Luwanika Mlera
In nature, vector-borne flaviviruses are persistently cycled between either the tick or mosquito vector and small mammals such as rodents, skunks, and swine. These viruses account for considerable human morbidity and mortality worldwide. In...
Tom Coenye,Patrick Van Dijck,Thomas Bjarnsholt et al.
Tom Coenye et al.
Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence [0.03%]
毒抗毒系统模块参与伯克霍尔德菌染色体 cps 中的生物被膜滞留性
Heleen Van Acker,Andrea Sass,Inne Dhondt et al.
Heleen Van Acker et al.
Biofilms are involved in the recalcitrance of infections due to the presence of persister cells. Although the molecular basis of persistence is still largely unknown, toxin-antitoxin modules (TA) are thought to play a role in this process. ...
Remote monitoring of the progression of primary pneumonic plague in Brown Norway rats in high-capacity, high-containment housing [0.03%]
用于高容量隔离饲养箱中布朗挪威大鼠原发性肺鼠疫远程监测的影像学方法研究进展
Eric A Coate,Andrew G Kocsis,Kristen N Peters et al.
Eric A Coate et al.
Development of new vaccines, diagnostics, and therapeutics for biodefense or other relatively rare infectious diseases is hindered by the lack of naturally occurring human disease on which to conduct clinical trials of efficacy. To overcome...