Effects of prime-boost strategies on the protective efficacy and immunogenicity of a PLGA (85:15)-encapsulated Chlamydia recombinant MOMP nanovaccine [0.03%]
PLGA微球包载的重组MOMP纳米疫苗不同免疫策略对其免疫原性和保护效力的影响
Rajnish Sahu,Richa Verma,Timothy E Egbo et al.
Rajnish Sahu et al.
To begin to optimize the immunization routes for our reported PLGA-rMOMP nanovaccine [PLGA-encapsulated Chlamydia muridarum (Cm) recombinant major outer membrane protein (rMOMP)], we compared two prime-boost immunization strategies [subcuta...
Comparative analysis of genomic characteristics and immune response between Mycobacterium tuberculosis strains cultured continuously for 25 years and H37Rv [0.03%]
连续培养25年的结核分枝杆菌菌株与H37Rv的基因组特征及免疫反应的比较分析
Chuanzhi Zhu,Jing Dong,Yuheng Duan et al.
Chuanzhi Zhu et al.
Tuberculosis (TB) continues to pose a significant global health challenge, emphasizing the critical need for effective preventive measures. Although many studies have tried to develop new attenuated vaccines, there is no effective TB vaccin...
Comparative Study
Pathogens and disease. 2024 Feb 7:82:ftae014. DOI:10.1093/femspd/ftae014 2024
Chlamydia trachomatis upregulates lncRNA CYTOR to mediate autophagy through miR-206/MAPK1 axis [0.03%]
沙眼衣原体通过miR-206/MAPK1轴上调长链非编码RNA CYTOR介导自噬反应
Shan Cheng,Yi Liu,Bei He et al.
Shan Cheng et al.
Chlamydia trachomatis infection can be regulated by autophagy-related genes. LncRNA CYTOR has been proven to be involved in autophagy. In this research, we investigated the role of CYTOR in autophagy induced by C. trachomatis and the potent...
Leprosy reactions: Unraveling immunological mechanisms underlying tissue damage in leprosy patients [0.03%]
反应性炎症在麻风病发病机制中的作用及免疫学机制研究进展
Héctor Serrano-Coll,Eric L Wan,Lina Restrepo-Rivera et al.
Héctor Serrano-Coll et al.
Leprosy is a chronic granulomatous infectious and disabling disease caused by two mycobacteria, Mycobacterium leprae and Mycobacterium lepromatosis. Acute inflammatory responses, known as leprosy reactions, are significant contributors to d...
Charlotte Abell-King,Alaska Pokhrel,Scott A Rice et al.
Charlotte Abell-King et al.
Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course is known on a macroscale, bacterial behavio...
Overcoming antibiotic resistance: non-thermal plasma and antibiotics combination inhibits important pathogens [0.03%]
克服抗生素耐药性：非热等离子体和抗生素联用抑制重要致病菌
Eva Vaňková,Jaroslav Julák,Anna Machková et al.
Eva Vaňková et al.
Antibiotic resistance (ATBR) is increasing every year as the overuse of antibiotics (ATBs) and the lack of newly emerging antimicrobial agents lead to an efficient pathogen escape from ATBs action. This trend is alarming and the World Healt...
Disrupting quorum sensing as a strategy to inhibit bacterial virulence in human, animal, and plant pathogens [0.03%]
扰乱群体感应作为抑制人类、动物和植物病原体细菌毒力的策略
Mélanie Gonzales,Baptiste Kergaravat,Pauline Jacquet et al.
Mélanie Gonzales et al.
The development of sustainable alternatives to conventional antimicrobials is needed to address bacterial virulence while avoiding selecting resistant strains in a variety of fields, including human, animal, and plant health. Quorum sensing...
Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013 [0.03%]
2012至2013年冬季荷兰呼吸道病原体患病率及黏膜细胞因子水平的横断面观察研究
Puck B van Kasteren,Anne T Gelderloos,Mioara Alina Nicolaie et al.
Puck B van Kasteren et al.
Respiratory pathogens can cause severe disease and even death, especially in the very young and very old. Studies investigating their prevalence often focus on individuals presenting to healthcare providers with symptoms. However, the desig...
Observational Study
Pathogens and disease. 2024 Feb 7:82:ftae010. DOI:10.1093/femspd/ftae010 2024
Protective anti-chlamydial vaccine regimen-induced CD4+ T cell response mediates early inhibition of pathogenic CD8+ T cell response following genital challenge [0.03%]
保护性沙眼衣原体疫苗诱导的CD4+T细胞应答介导生殖器部位感染后早期抑制致病性的CD8+T细胞应答
Ashlesh K Murthy,Erika Wright-McAfee,Katerina Warda et al.
Ashlesh K Murthy et al.
We have demonstrated previously that TNF-α-producing CD8+ T cells mediate chlamydial pathogenesis, likely in an antigen (Ag)-specific fashion. Here we hypothesize that inhibition of Ag-specific CD8+ T cell response after immunization and/o...
From fever to action: diagnosis, treatment, and prevention of acute undifferentiated febrile illnesses [0.03%]
从发热到行动：急性非特异性发热性疾病的诊断、治疗和预防
Muttiah Barathan
Muttiah Barathan
Acute Undifferentiated Febrile Illness (AUFI) presents a clinical challenge, often characterized by sudden fever, non-specific symptoms, and potential life-threatening implications. This review highlights the global prevalence, types, chall...