Rickettsia-host interaction: strategies of intracytosolic host colonization [0.03%]
立克次氏体与宿主的相互作用：胞内宿主 colonization 策略
Oliver H Voss,M Sayeedur Rahman
Oliver H Voss
Bacterial infection is a highly complex biological process involving a dynamic interaction between the invading microorganism and the host. Specifically, intracellular pathogens seize control over the host cellular processes including membr...
Jennifer D Helble,Michael N Starnbach
Jennifer D Helble
Chlamydia trachomatis is the most commonly reported sexually transmitted infection in the United States. The high prevalence of infection and lack of a vaccine indicate a critical knowledge gap surrounding the host's response to infection a...
Fungal immunity and pathogenesis in mammals versus the invertebrate model organism Galleria mellonella [0.03%]
哺乳动物与无脊椎动物模型模式生物Galleria mellonella的真菌免疫和病原学
Daniel F Q Smith,Arturo Casadevall
Daniel F Q Smith
In recent decades, Galleria mellonella (Lepidoptera: Pyralidae) have emerged as a model system to explore experimental aspects of fungal pathogenesis. The benefits of the G. mellonella model include being faster, cheaper, higher throughput ...
Immunopathogenesis of genital Chlamydia infection: insights from mouse models [0.03%]
小鼠模型研究生殖道沙眼衣原体感染的免疫病理机制
Jacob Dockterman,Jörn Coers
Jacob Dockterman
Chlamydiae are pathogenic intracellular bacteria that cause a wide variety of diseases throughout the globe, affecting the eye, lung, coronary arteries and female genital tract. Rather than by direct cellular toxicity, Chlamydia infection g...
Comparative study of sodium bicarbonate- and magnesium hydroxide-based gastric antacids for the effectiveness of Salmonella delivered Brucella antigens against wild type challenge in BALB/c mice [0.03%]
小鼠模型中比较胃用碱性抗酸剂（碳酸氢钠和氢氧化镁）对沙门氏菌递呈布氏杆菌疫苗效力的影响研究
Chamith Hewawaduge,Amal Senevirathne,Myeon-Sik Yang et al.
Chamith Hewawaduge et al.
We compared the effects of two antacid formulations based on sodium bicarbonate and magnesium hydroxide on a Salmonella-delivered oral Brucella live attenuated vaccine. We conducted a series of in vitro and in vivo experiments to investigat...
Comparative Study
Pathogens and disease. 2021 Feb 19;79(2):ftab002. DOI:10.1093/femspd/ftab002 2021
Enhanced immune responses, PI3K/AKT and JAK/STAT signaling pathways following hepatitis C virus eradication by direct-acting antiviral therapy among Egyptian patients: a case control study [0.03%]
直接抗病毒治疗根除丙型肝炎病毒感染后埃及患者的免疫反应及PI3K / AKT和JAK / STAT信号通路：一项病例对照研究
Haidi Karam-Allah Ramadan,Gamal Badr,Nancy K Ramadan et al.
Haidi Karam-Allah Ramadan et al.
The use of direct-acting antivirals (DAAs) therapy for the treatment of hepatitis C virus (HCV) results in a high-sustained virological response (SVR) and subsequently alters liver immunologic environment. However, hepatocellular carcinoma ...
Exploring Galleria mellonella larval model to evaluate antibacterial efficacy of Cecropin A (1-7)-Melittin against multi-drug resistant enteroaggregative Escherichia coli [0.03%]
用瓜实金小蜂幼虫模型评估Cecropin A(1-7)-Melittin对多重耐药聚集性大肠杆菌的抗菌效果
Jess Vergis,S V S Malik,Richa Pathak et al.
Jess Vergis et al.
High throughput in vivo laboratory models is need for screening and identification of effective therapeutic agents to overcome microbial drug-resistance. This study was undertaken to evaluate in vivo antimicrobial efficacy of short-chain an...
Got mutants? How advances in chlamydial genetics have furthered the study of effector proteins [0.03%]
有突变体吗？小密柱菌遗传学的进步如何促进了效应蛋白的研究
Shelby E Andersen,Lanci M Bulman,Brianna Steiert et al.
Shelby E Andersen et al.
Chlamydia trachomatis is the leading cause of infectious blindness and a sexually transmitted infection. All chlamydiae are obligate intracellular bacteria that replicate within a membrane-bound vacuole termed the inclusion. From the confin...
Biobank for multidrug-resistant tuberculosis research: importance of sequential samples [0.03%]
耐多药结核病研究生物样本库：连续采样标本的重要性
Yoohyun Hwang,Jiyeon Kim,Seungkyu Park et al.
Yoohyun Hwang et al.
Since 2013, Masan National Tuberculosis Hospital has collected standardized specimens from its tuberculosis patients, which include a large number of multidrug-resistant strains. The repository collects matched participants and their bacill...
Sofie Føns,Karen A Krogfelt
Sofie Føns
Since the outbreak of COVID-19, the world has raced to understand and accurately diagnose infection caused by SARS-CoV-2. Today, hundreds of commercial antibody tests are on the market despite often lacking proper validation and with unsati...