Conditional impairment of Coxiella burnetii by glucose-6P dehydrogenase activity [0.03%]
葡萄糖-6-磷酸脱氢酶活性对烧炎体的条件性抑制作用
Savannah E Sanchez,Anders Omsland
Savannah E Sanchez
Coxiella burnetii is a bacterial obligate intracellular parasite and the etiological agent of query (Q) fever. While the C. burnetii genome has been reduced to ∼2 Mb as a likely consequence of genome streamlining in response to parasitism,...
Mycobacterium tuberculosis (MTB) antigen-induced upregulation of interleukin-35 expression in patients with MTB infection: In vitro blockade of the effects of interleukin-35 on T lymphocyte subsets [0.03%]
结核分枝杆菌抗原诱导的结核病患者IL-35表达上调及体外阻断IL-35作用的研究
Hongbin Jiang,Beinian Cui,Jun Zhang
Hongbin Jiang
Immunosuppressive interleukin-35 (IL-35) serum concentrations were analyzed in patients with active pulmonary Mycobacterium tuberculosis (MTB) infections (PTB), PTB patients after two months treatment (stable PTB) and healthy controls. IL-3...
Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients [0.03%]
急性风湿热患者胶原肽和链球菌胶原样1蛋白的抗体反应
Devaki H Pilapitiya,Paul W R Harris,Paulina Hanson-Manful et al.
Devaki H Pilapitiya et al.
Acute rheumatic fever (ARF) is a serious post-infectious immune sequelae of Group A streptococcus (GAS). Pathogenesis remains poorly understood, including the events associated with collagen autoantibody generation. GAS express streptococca...
Bacterial colonization of bladder urothelial cells in women with refractory Detrusor Overactivity: the effects of antibiotic therapy [0.03%]
难治性膀胱过度活动症患者膀胱移行上皮细菌定植及抗生素治疗的影响
S Ognenovska,Z Chen,C Mukerjee et al.
S Ognenovska et al.
Bacterial infection may have a pathophysiological role in refractory Detrusor Overactivity (DO). The aim of this study was to observe any impact of antibiotic therapy upon bacterial colonization of urothelial cells, and to determine whether...
Randomized Controlled Trial
Pathogens and disease. 2021 Jul 2;79(6):ftab031. DOI:10.1093/femspd/ftab031 2021
Establishment of a localized acute implant-associated Staphylococcus aureus bone infection model in sheep [0.03%]
绵羊局部急性金黄色葡萄球菌种植体感染骨组织模型的建立
Karina Klein,Tiziano A Schweizer,Katharina Siwy et al.
Karina Klein et al.
Orthopedic implant-associated bacterial infections with Staphylococcus aureus constitute a major clinical problem, and large pre-clinical animal models remain scarce. The aim of this study was to establish a standardized method of a localiz...
High-resolution crystal structure of the Borreliella burgdorferi PlzA protein in complex with c-di-GMP: new insights into the interaction of c-di-GMP with the novel xPilZ domain [0.03%]
伯氏疏螺旋体PlzA蛋白与c-di-GMP复合物的高分辨率晶体结构：新型xPilZ结构域与c-di-GMP相互作用的新见解
Avinash Singh,Jerilyn R Izac,Edward J A Schuler et al.
Avinash Singh et al.
In the tick-borne pathogens, Borreliella burgdorferi and Borrelia hermsii, c-di-GMP is produced by a single diguanylate cyclase (Rrp1). In these pathogens, the Plz proteins (PlzA, B and C) are the only c-di-GMP receptors identified to date ...
Biostatistical prediction of genes essential for growth of Anaplasma phagocytophilum in a human promyelocytic cell line using a random transposon mutant library [0.03%]
采用随机转座子突变文库预测欧文菌在人类早幼粒细胞系中生长所必需的基因
M Catherine O&#x;Conor,Michael J Herron,Curtis M Nelson et al.
M Catherine O&#x;Conor et al.
Anaplasma phagocytophilum (Ap), agent of human anaplasmosis, is an intracellular bacterium that causes the second most common tick-borne illness in North America. To address the lack of a genetic system for these pathogens, we used random H...
Andrea Marshall,Angela D Pack,Sarah Afua Owusu et al.
Andrea Marshall et al.
While it is commonly thought that microaggressions are isolated incidents, microaggressions are ingrained throughout the academic research institution (Young, Anderson and Stewart 2015; Lee et al. 2020). Persons Excluded from science becaus...
Innate immune response: ally or enemy in cutaneous leishmaniasis? [0.03%]
天然免疫反应：老魔-cutaneous leishmaniasis新盟友还是敌人？
Héctor Serrano-Coll,Nora Cardona-Castro,Ana Pilar Ramos et al.
Héctor Serrano-Coll et al.
Cutaneous leishmaniasis (CL) is an infectious and neglected disease caused by parasites of the genus Leishmania, which produces a wide spectrum of cutaneous manifestations. CL research has shown that the innate immune activity of cells such...
Caitlan D Byerly,LaNisha L Patterson,Jere W McBride
Caitlan D Byerly
Intracellular bacteria have evolved various strategies to evade host defense mechanisms. Remarkably, the obligately intracellular bacterium, Ehrlichia chaffeensis, hijacks host cell processes of the mononuclear phagocyte to evade host defen...