Plasmodium falciparum PfRUVBL proteins bind at the TARE region and var gene promoter located in the subtelomeric region [0.03%]
恶性疟原虫PfRUVBL蛋白结合在亚端粒区的TARE和var基因启动子区域
Himani Saxena,Ashish Gupta
Himani Saxena
In order to survive and establish infection, the Plasmodium parasite employs various strategies to evade the host immune response. The var genes family, a repertoire of 60 genes, expresses parasite-specific protein PfEMP1, a variable surfac...
AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia [0.03%]
AZI2 正向调节流感诱发的儿童肺炎中1型干扰素的诱导作用
Meili Wei,Yanfei Zheng,Jing Xu et al.
Meili Wei et al.
5-azacytidine-induced protein 2 (AZI2) is known to have a crucial role in antiviral innate immunity. This study aims to explore the roles of AZI2 in influenza-trigger pediatric pneumonia and its molecular mechanism. qPCR and immunoblotting ...
A comprehensive review on classifying fast-acting and slow-acting antimalarial agents based on time of action and target organelle of Plasmodium sp [0.03%]
基于作用时间和靶向宿主细胞器的快速和慢速抗疟药的综合分类评论
Monika Mariebernard,Abhinab Mohanty,Vinoth Rajendran
Monika Mariebernard
The clinical resistance towards malarial parasites has rendered many antimalarials ineffective, likely due to a lack of understanding of time of action and stage specificity of all life stages. Therefore, to tackle this problem a more incis...
Discovery of spirooxindole-pyrrolidine heterocyclic hybrids with potent antifungal activity against fungal pathogens [0.03%]
一类具有抗真菌活性的Spirooxindole-吡咯烷杂环化合物的新发现
Hannah Dowdy,Raju Suresh Kumar,Abdulrahman I Almansour et al.
Hannah Dowdy et al.
Fungal pathogens mainly Candida and Cryptococcus species causes serious life-threating infections to humans, especially in individuals who are immunocompromised. Increasing frequency of antifungal drug resistance along with paucity of FDA-a...
Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection [0.03%]
维生素D通过诱导LL-37调节人单核巨噬细胞源小吞噬细胞在登革病毒二型感染中的天然免疫反应
Jorge Andrés Castillo,Diana Marcela Giraldo,Jolanda M Smit et al.
Jorge Andrés Castillo et al.
Epidemics of dengue, an acute and potentially severe disease caused by mosquito-borne dengue virus (DENV), pose a major challenge to clinicians and health care services across the sub(tropics). Severe disease onset is associated with a dysr...
Anmol Kulshrestha,Pratima Gupta
Anmol Kulshrestha
Polymicrobial biofilm (PMBF) formation during multispecies infection is a serious threat growing worldwide. According to CDC, microbial biofilm infection covers more than 65% of total infection. In many diseases, their natural habitat does ...
Chinonyelum A Okoye,Emeka Nweze,Chibuike Ibe
Chinonyelum A Okoye
Invasive candidiasis is a serious, progressive, and potentially deadly infection that can affect the brain, heart, bones, eyes, and other parts of the body. It is associated with risk factors such as the use of indwelling medical devices, p...
Andrea G Marshall,Lillian J Brady,Caroline B Palavicino-Maggio et al.
Andrea G Marshall et al.
Working with multiple mentors is a critical way for students to expand their network, gain opportunities, and better prepare for future scholastic or professional ventures. However, students from underrepresented groups (UR) are less likely...
Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish [0.03%]
血管通透性抑制可调节斑马鱼宿主白细胞向鼠疫分枝杆菌肉芽肿的募集
Julia Y Kam,Tina Cheng,Danielle C Garland et al.
Julia Y Kam et al.
Mycobacterial granuloma formation involves significant stromal remodeling including the growth of leaky, granuloma-associated vasculature. These permeable blood vessels aid mycobacterial growth, as antiangiogenic or vascular normalizing the...
Tannerella forsythia strains differentially induce interferon gamma-induced protein 10 (IP-10) expression in macrophages due to lipopolysaccharide heterogeneity [0.03%]
由于脂多糖的异质性，福氏威利安姆菌株差异诱导巨噬细胞中干扰素γ诱导蛋白10（IP-10）的表达
Sreedevi Chinthamani,Rajendra P Settem,Kiyonobu Honma et al.
Sreedevi Chinthamani et al.
Tannerella forsythia is strongly implicated in the development of periodontitis, an inflammatory disease that destroys the bone and soft tissues supporting the tooth. To date, the knowledge of the virulence attributes of T. forsythia specie...