Garadacimab and the future of hereditary angioedema prophylaxis: a step upstream in the bradykinin pathway [0.03%]
garadacimab和遗传性血管水肿预防的未来： bradykinin途径的上游步骤
Harshika Khaim Chandani,Syeda Fadak Zahra Hujjat,Devya Khaim Chandani et al.
Harshika Khaim Chandani et al.
Hereditary angioedema (HAE) is a rare autosomal dominant disorder characterized by recurrent, potentially life-threatening episodes of bradykinin-mediated angioedema affecting the skin, gastrointestinal tract, and upper airway. Despite the ...
Isolated subcutaneous sarcoidosis presenting as multiple nodules: a rare case with diagnostic challenges [0.03%]
表现为多发结节的孤立性皮肤结节病一例及其诊断难点
Yoseph M Habte,Binyam M Habte,Makida M Habte et al.
Yoseph M Habte et al.
Introduction and importance: Isolated subcutaneous sarcoidosis is an uncommon form of sarcoidosis, typically presenting as firm, painless nodules beneath clinically normal skin. Its rarity, especially in male patients or ...
Secondary hemophagocytic lymphohistiocytosis following bacterial pneumonia managed with dexamethasone monotherapy: a case report [0.03%]
一例由细菌性肺炎继发的第二次噬血细胞综合征单用糖皮质激素治疗病例报告
Pukar Kc,Aashish Kumar Jha,Nikita Gautam et al.
Pukar Kc et al.
Introduction: Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome in adults, resulting from uncontrolled immune activation and a cytokine storm, and is frequently misdiagnosed because i...
Hyperuricemia in heart failure with preserved ejection fraction: pathophysiological insights and therapeutic perspectives - a narrative review [0.03%]
射血分数保留的心力衰竭中的高尿酸血症：病理生理学见解和治疗前景——叙述性综述
Manahil Riaz,Aakash Ghanwani,Maira Khan et al.
Manahil Riaz et al.
Heart failure with preserved ejection fraction (HFpEF) constitutes a growing burden worldwide, with hyperuricemia emerging as a prominent comorbidity. This review explores the prevalence, pathophysiological mechanisms, and therapeutic impli...
Correlation of pulse oximetry with arterial blood gas-derived oxygen saturation in ICU patients on supplemental oxygen: a cross-sectional study [0.03%]
ICU吸氧患者的脉搏血氧饱和度与动脉血气氧饱和度相关性分析：横断面研究
Bikash Pandey,Birendra Jha,Sumit Shahi et al.
Bikash Pandey et al.
Introduction: Oxygen is essential for maintaining proper bodily functions and is closely regulated within the body. Hypoxemic patients, who have lower than normal oxygen levels in their blood, require precise monitoring t...
Pillar pain after carpal tunnel release: an evidence-based review of pathophysiology, diagnostic strategies, and a structured clinical decision-making framework [0.03%]
腕管松解术后前臂痛：病理生理、诊断策略及临床决策框架的循证评价
Aidin Arabzadeh,Seyyed Saeed Khabiri,Seyyed Hadi Kalantar et al.
Aidin Arabzadeh et al.
Pillar pain is a frequent, yet often overlooked, complication after carpal tunnel release (CTR). Although usually self-limiting, it can persist and interfere with recovery, hand function, and patient satisfaction. The pain typically localiz...
Gene silencing versus protein stabilization in transthyretin amyloid cardiomyopathy: contextualizing the HELIOS-B results and the road to precision agent selection [0.03%]
转甲状腺素蛋白淀粉样变性心肌病中基因沉默与蛋白质稳定的作用：HELIOS-B研究结果的背景分析及精准药物选择之路
Sarum Ali Khan,Taimoor Ali,Muhammad Sajjad Ul Haque et al.
Sarum Ali Khan et al.
Transthyretin amyloid cardiomyopathy (ATTR-CM) now has three approved disease-modifying agents: tafamidis, acoramidis, and vutrisiran, representing two mechanistically distinct classes: TTR tetramer stabilizers and RNA interference (RNAi) g...
Mosquito-borne viruses and male infertility: Zika was just the beginning - the impact of dengue on sperm DNA integrity [0.03%]
蚊媒病毒与男性不育：寨卡病毒只是个开始——登革热对精子DNA完整性的影响
Hafsa Tariq,Dua Asim,Mahnoor Sheikh et al.
Hafsa Tariq et al.
Dengue is resurging globally (~14 million cases in 2024). Emerging evidence suggests that dengue infection may transiently impair male fertility. Acute dengue has been associated with reversible declines in sperm count, with potential incre...
Superior sagittal sinus thrombosis presented as a migraine headache with normal D-dimer: a case report and literature review [0.03%]
以正常D-二聚体水平的偏头痛为表现的上矢状窦血栓形成病例报道及文献复习
Mohammedsadeq A Shweliya,Khadeeja Ali Hamzah,Yousif Hameed Kurmaha et al.
Mohammedsadeq A Shweliya et al.
Introduction: Superior sagittal sinus thrombosis (SSST) is a rare type of cerebral venous sinus thrombosis (CVST), characterized by blood clot formation in the superior sagittal sinus, leading to increased intracranial pr...
Superinfected appendiceal mucocele with a giant appendicolith: a rare entity in a common surgical emergency - a case report [0.03%]
超感染阑尾黏液湖伴巨结石：常见急症手术中罕见病例——个例报告
Bhawesh Bhattarai,Bikash K Shah,Prashant Ghimire et al.
Bhawesh Bhattarai et al.
Introduction: Appendiceal mucocele (AM) is a rare surgical emergency, commonly caused by an appendicolith. An appendicolith larger than 2 cm is termed "giant," which is rare and carries a high risk of perforation. This ca...