Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies [0.03%]
Slack钾通道的小分子抑制剂可潜在用于治疗儿童癫痫症
Alshaima&#x;a M Qunies,Kyle A Emmitte
Alshaima&#x;a M Qunies
Slack channels are sodium-activated potassium channels that are encoded by the KCNT1 gene. Several KCNT1 gain of function mutations have been linked to malignant migrating partial seizures of infancy. Quinidine is an anti-arrhythmic drug th...
Baicalein: promising therapeutic applications with special reference to published patents [0.03%]
黄芩素：有前景的治疗应用（特别参考已发表专利）
Shubhangi Gupta,Harpal S Buttar,Ginpreet Kaur et al.
Shubhangi Gupta et al.
Baicalein is a medicinally important flavonoid present in Scutellaria baicalensis, which has numerous biological benefits like anti-oxidant, anti-inflammatory, antihepatotoxicity, anticancer properties, etc. Recent studies have revealed tha...
Multicomponent crystal compromising dasatinib and selected co-crystals formers: a patent evaluation of EP2861589B1 [0.03%]
有关多组分晶体及所选共晶形成剂的专利评估：EP2861589B1
Ritu Rathi,Inderbir Singh
Ritu Rathi
Cocrystallization has gained significant prominence in pharmaceutical product development because of the enhancement of physical, chemical and pharmacological properties of active pharmaceutical ingredients, such as stability, solubility, d...
Maricruz Anaya-Ruiz,Martin Perez-Santos
Maricruz Anaya-Ruiz
Cancer drug repurposing is an attractive approach that leads to savings in time and investment. Adapalene, the first medical application of which was for the treatment of acne, has been described as a repurposing drug for the treatment of v...
Small-molecule inhibitor PD-1/PD-L1 interaction for colorectal cancer treatment [0.03%]
小分子抑制剂PD-1/PD-L1结直肠癌治疗中的相互作用
Maricruz Anaya-Ruiz,Martin Perez-Santos
Maricruz Anaya-Ruiz
Inhibition of the PD-1/PD-L1 pathway is a target for the development of new therapies. US10710986 patent describes a small molecule that targets PDL-1/PD-1 interactions and triggers antitumor activity against colorectal cancer. However, it ...
Hermann Am Mucke
Hermann Am Mucke
A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.
Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review [0.03%]
用于色谱分析的绿色或生物基溶剂的近期专利与市场概述：综述
Abdul Muheem,Mohammed Asadullah Jahangir,Sanjula Baboota et al.
Abdul Muheem et al.
Green solvents (GS) in chromatography originate from green chemistry. Therefore, using GSs in liquid chromatographic analysis to separate drugs and chemicals is an emerging approach to reduce hazardous chemicals in nature. The Orbit Intelli...
Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges [0.03%]
寨卡病毒疫苗和治疗方法的专利状况及挑战与突破
Sandro G Viveiros Rosa,Wilson C Santos
Sandro G Viveiros Rosa
Barbara Miziak,Stanislaw J Czuczwar
Barbara Miziak
A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier [0.03%]
一种用于通过皮肤屏障输送生物大分子阴离子的无毒离子液体组合物
Neeraj Kumar,Balraj Saini,Rajwinder Kaur
Neeraj Kumar
The development of biocompatible ionic liquids is needed in order to explore their vastly underutilized pharmaceutical potential. US10912834 patent discloses ionic liquids comprising macromolecular biological anions and alkylated cations, w...