Dipesh Baradia,Nirav Khatri,Sonia Trehan et al.
Dipesh Baradia et al.
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vascular system, which may lead to right-heart failure or early death in the absence of effective treatment. The current therapy for PAH mainly includes phospho...
Learning from practice: compulsory licensing cases and access to medicines [0.03%]
从实践中学习：强制许可案例与药品可及性
Beatrice Stirner
Beatrice Stirner
In March 2012, India issued its first compulsory license for a kidney cancer drug. India is one of several countries that have applied the flexibility incorporated in the Agreement on Trade-related Aspects of IP rights. It is expected that ...
Meihua Tu,Jeffrey A Pfefferkorn,Angel Guzman-Perez et al.
Meihua Tu et al.
One gap in current patent-mining practice is the lack of tools to build SAR knowledge. Here, we report a novel technique that enabled us to derive useful SAR information from the exemplified structures of a series of patents. In our approac...
Nancy P Pei,J Sheldon Hamilton
Nancy P Pei
Gerd Stötter
Gerd Stötter
Laura Reynolds,Brian Cordery
Laura Reynolds
Patents and the US FDA's definition of 'cocrystal': an ordinary and customary meaning? [0.03%]
专利与美国FDA的共晶定义：“普通和惯常意义”?
Jeffrey A Lindeman
Jeffrey A Lindeman
Edlyn S Simmons
Edlyn S Simmons
Pierfausto Seneci
Pierfausto Seneci
The quest for potent and selective targeted therapies in anticancer research is taking advantage of apoptosis-related mechanisms of action to identify a number of novel clinical candidates. This review is chemically focused on small molecul...