Unlocking the potential of CRISPR technology for improving livelihoods in Africa [0.03%]
释放CRISPR技术在非洲改善民生的潜力
Reagan Mudziwapasi,Abigarl Ndudzo,Rutendo Patricia Nyamusamba et al.
Reagan Mudziwapasi et al.
Africa is burdened with food shortages and plant, animal and human diseases. Some of these can be ameliorated by adopting genome editing technologies such as CRISPR. This technology is considered better than its predecessors, Zinc-finger nu...
Christopher Isaac,Trushar R Patel,Athanasios Zovoilis
Christopher Isaac
Advances in sequencing technologies and bioinformatic analysis techniques have greatly improved our understanding of various classes of RNAs and their functions. Despite not coding for proteins, non-coding RNAs (ncRNAs) are emerging as esse...
Luc Roberts,Hans-Joachim Wieden
Luc Roberts
Internal ribosome entry sites (IRESs) are cis-acting RNA elements capable of recruiting ribosomes and initiating translation on an internal portion of an mRNA. This is divergent from canonical eukaryotic translation initiation, where the 5'...
Shivali S Joshi,Carla S Coffin
Shivali S Joshi
The hepatitis B virus (HBV) is predominantly a hepatotropic virus but also infects cells of the lymphatic system. HBV genomes (DNA, messenger (m)RNA, covalently closed circular (ccc) DNA) and proteins have been found in extrahepatic sites s...
Franz Zemp,Jahanara Rajwani,Douglas J Mahoney
Franz Zemp
The family Rhabdoviridae (RV) comprises a large, genetically diverse collection of single-stranded, negative sense RNA viruses from the order Mononegavirales. Several RV members are being developed as live-attenuated vaccine vectors for the...
Combating the HIV reservoirs [0.03%]
抗击HIV贮存库
Guido van Marle,Deirdre L Church,Frank van der Meer et al.
Guido van Marle et al.
Impressive advances have been made in the treatment and management of HIV-1 infected individuals. Combination antiretroviral therapy (cART) has turned HIV-1 infection from an almost invariable deadly infectious disease, to a lifelong manage...
Les P Nagata,Chad R Irwin,Wei-Gang Hu et al.
Les P Nagata et al.
The past few years have seen a rash of emerging viral diseases, including the Ebola crisis in West Africa, the pandemic spread of chikungunya, and the recent explosion of Zika in South America. Vaccination is the most reliable and cost-effe...
Vanessa Meier-Stephenson,Tyler Mrozowich,Mimi Pham et al.
Vanessa Meier-Stephenson et al.
Viruses hijack the host cell machinery and recruit host proteins to aid their replication. Several host proteins also play vital roles in inhibiting viral replication. Emerging class of host proteins central to both of these processes are t...
Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review [0.03%]
针对宿主蛋白激酶R的病毒蛋白质以逃避先天性免疫反应：综述文章
Edis Dzananovic,Sean A McKenna,Trushar R Patel
Edis Dzananovic
The innate immune system offers a first line of defense by neutralizing foreign pathogens such as bacteria, fungi, and viruses. These pathogens express molecules (RNA and proteins) that have discrete structures, known as the pathogen-associ...