PLCε promotes the Warburg effect and tumorigenesis through AKT/GSK3β/Cdc25a in bladder cancer [0.03%]
PLCε通过AKT/GSK3β/Cdc25a促进膀胱癌的瓦堡效应和肿瘤发生
Yanru Fan,Yanni Hao,Chunkai Zhu et al.
Yanru Fan et al.
Phospholipase C epsilon (PLCε) is a oncogene in various malignancies and regulates diverse cellular functions. But understanding of the relation between PLCε and glycolytic pathways has not been clearly identified. In the present study, w...
A pharmacokinetic-pharmacodynamic model based on the SSA-1DCNN-Attention network and the semicompartment method [0.03%]
基于SSA-1DCNN-Attention网络和半腔室法的药动学药效学模型
Jieyu Yang,Yong Li
Jieyu Yang
To solve the problem of inaccurate prediction caused by the lack of representativeness of samples due to the small sample size of the collected clinical data when using machine learning methods to predict drug concentration in plasma and de...
The role of ultrasonic cardiogram in the diagnosis of hypertension complicated with type 2 diabetes mellitus [0.03%]
二维超声心动图在高血压合并2型糖尿病患者中的诊断价值分析
Lingling Zhou,Qingdong Zhang,Li Wang
Lingling Zhou
Hypertension diabetes mellitus is one of the serious complications of hypertension. In this study, ambulatory blood pressure monitoring (ABPM) and ultrasonic cardiogram (UCG) were used to investigate the cardiac changes and its influencing ...
MicroRNA-30a depresses hepatic stellate cell activation against liver fibrosis through blockade of the TGF-β1/Smad2/3 pathway [0.03%]
微小核糖核酸-30a通过阻断转化生长因子-β1/Smad2/3途径抑制肝星状细胞活化对抗肝纤维化
Yipeng Pan,Bo You,Xue Zhao et al.
Yipeng Pan et al.
This study explored the mechanism of microRNA (miR)-30a in the activation of hepatic stellate cells (HSCs) to deepen the understanding of the pathogenesis of liver fibrosis. Subsequent to knockdown and ectopic experiments, HSCs were induced...
Unveiling the role of emerging metagenomics for the examination of hypersaline environments [0.03%]
新兴宏基因组学在高盐环境考察中作用初探
Kiran Dindhoria,Vivek Manyapu,Ashif Ali et al.
Kiran Dindhoria et al.
Hypersaline ecosystems are distributed all over the globe. They are subjected to poly-extreme stresses and are inhabited by halophilic microorganisms possessing multiple adaptations. The halophiles have many biotechnological applications su...
Single-cell RNA sequencing and transcriptomic analysis reveal key genes and regulatory mechanisms in sepsis [0.03%]
单细胞RNA测序和转录组分析揭示了脓毒症中的关键基因及调控机制
Qingping Mo,Qingying Mo,Fansen Mo
Qingping Mo
The pathogenesis of sepsis, with a high mortality rate and often poor prognosis, has not been fully elucidated. Therefore, an in-depth study on the pathogenesis of sepsis at the molecular level is essential to identify key sepsis-related ge...
Knockdown of ERO1L attenuates tumor growth, migration and invasion in lung adenocarcinoma through Wnt/β‑catenin pathway [0.03%]
ERO1L敲低通过Wnt/β-catenin信号转导通路抑制肺腺癌的生长、迁移和侵袭
Shupeng Zhang,Meng Zhang,Weichang Ma et al.
Shupeng Zhang et al.
Recent studies confirm the critical roles of endoplasmic reticulum oxidoreductase 1 alpha (ERO1L) in malignant behavior of various cancers. Nevertheless, what function ERO1L plays in lung adenocarcinoma (LUAD) remains uncovered. The express...
Tongmai Zhuke decoction restrains the inflammatory reaction of macrophages for carotid artery atherosclerosis by up-regulating lincRNA-Cox2 [0.03%]
通脉筑络汤通过上调lincRNA-Cox2抑制颈动脉粥样硬化巨噬细胞炎症反应
Sishuo Zhang,Yahan Wang,Haitao Li et al.
Sishuo Zhang et al.
To explore the mechanism of Tongmai Zhuke decoction for promoting blood circulation by taking carotid artery atherosclerosis (CAA) as an example, two sets of in-depth transcriptomic data as well as two sets of single-cell RNA sequencing dat...
Jayanti Mukherjee,Ramesh Sharma,Prasenjit Dutta et al.
Jayanti Mukherjee et al.
There is a vast development of artificial intelligence (AI) in recent years. Computational technology, digitized data collection and enormous advancement in this field have allowed AI applications to penetrate the core human area of special...
Clinical study on prescription used for invigorating spleen, reinforcing kidney and warming yang combined with calcium dobesilate in treatment of senile diabetic nephropathy [0.03%]
健脾固肾温阳法联合ドベルザ治疗糖尿病肾病临床研究
Lin Zhu,Jianqun Zhao,Qian Li
Lin Zhu
Objective: To analyze the clinical effect of prescription used for invigorating spleen, reinforcing kidney and warming yang combined with calcium dobesilate to treat senile diabetic nephropathy (DN). ...