Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway [0.03%]
Orientin通过抑制PI3K/AKT通路缓解软骨细胞衰老和骨关节炎
Haitao Chen,Siyi Liu,Junwei Xing et al.
Haitao Chen et al.
Aims: Osteoarthritis (OA) is a common degenerative disease that leads to pain, disability, and reduced quality of life. Orientin exhibits considerable anti-inflammatory and antioxidative properties, but its role in chondr...
The effect of metaphyseal holes and interposition material on the longitudinal growth stimulation of long bones in a rabbit model [0.03%]
兔模型中 metaphyseal 空洞和嵌入物质对长骨纵向生长刺激的影响
Byoung K Park,Kyoung-Mi Lee,Kyeong-Hyeon Park et al.
Byoung K Park et al.
Aims: It remains unclear which factors influence overgrowth of the tibia, resulting from the metaphyseal hole created during anterior cruciate ligament (ACL) reconstruction in skeletally immature patients. This study aime...
Yan Xiao,Zhang Yue,He Zijing et al.
Yan Xiao et al.
Published Erratum
Bone & joint research. 2025 Mar 13;14(3):223. DOI:10.1302/2046-3758.143.BJR-2025-00003 2025
Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis [0.03%]
全转录组关联研究衍生基因作为骨关节炎潜在可药物靶点的识别与验证
Xindie Zhou,Xinjian Ye,Jiapei Yao et al.
Xindie Zhou et al.
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, ...
Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration [0.03%]
机械压迫通过调节Runx2的O-连接的N-乙酰葡萄糖胺化作用诱导颞下颌关节髁突退行过程中软骨细胞肥大
Yan Xiao,Zhang Yue,He Zijing et al.
Yan Xiao et al.
Aims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remain...
Corrigendum [0.03%]
勘误表
Yayuan Guo,Xueliang Peng,Bin Cao et al.
Yayuan Guo et al.
Published Erratum
Bone & joint research. 2025 Mar 5;14(3):208. DOI:10.1302/2046-3758.143.BJR-2025-00002 2025
Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis [0.03%]
异常的同化作用通过药物治疗妨碍了骨关节炎软骨细胞的建设性代谢
Raquel Largo,Aranzazu Mediero,Cristina Villa-Gomez et al.
Raquel Largo et al.
Osteoarthritis (OA) is a highly prevalent and disabling disease with an unmet therapeutic need. The characteristic cartilage loss and alteration of other joint structures result from a complex interaction of multiple risk factors, with mech...
Zhaojing Guo,Hengzhen Li,Shide Jiang et al.
Zhaojing Guo et al.
Sarcopenia is an ageing-related disease featured by the loss of skeletal muscle quality and function. Advanced glycation end-products (AGEs) are a complex set of modified proteins or lipids by non-enzymatic glycosylation and oxidation. The ...
Rapid multiplex micro-ELISA assay for simultaneous measurement of synovial biomarkers : a potential aid in diagnosing periprosthetic joint infection? [0.03%]
用于同时测量滑液生物标志物的快速多路微elisa检测：辅助诊断假体周围关节感染的潜在方法？
Martina Maritati,Michael Vogl,Max Sonnleitner et al.
Martina Maritati et al.
Aims: The diagnosis of periprosthetic joint infection (PJI) remains a challenge, as no single diagnostic test shows high diagnostic accuracy. Recently, the measurement of synovial biomarkers has shown promising results. T...
Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting [0.03%]
新型不连接大鼠长骨模型的发展及前列腺素EP4选择性激动剂(AKDS001)联合髂骨移植的有效性评价
Daisuke Tateiwa,Masahiro Nishida,Joe Kodama et al.
Daisuke Tateiwa et al.
Aims: Nonunion occurs when a fracture fails to heal permanently, often necessitating surgical intervention to stimulate the bone healing response. Current animal models of long-bone nonunion do not adequately replicate hu...