Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations [0.03%]
从结晶学、NMR及MD模拟中了解Eph受体-配体界面的蛋白质动力学特征
Haina Qin,Liangzhong Lim,Jianxing Song
Haina Qin
Background: The role of dynamics in protein functions including signal transduction is just starting to be deciphered. Eph receptors with 16 members divided into A- and B- subclasses are respectively activated by 9 A- and...
Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates [0.03%]
利用检查点纺锤体组装的默认约束估计相关化学速率
Khanh Dao Duc,David Holcman
Khanh Dao Duc
Background: Default activation of the spindle assembly checkpoint provides severe constraints on the underlying biochemical activation rates: on one hand, the cell cannot divide before all chromosomes are aligned, but on ...
Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data [0.03%]
基于原子分辨率数据的膜蛋白中氨基酸识别脂质的倾向性分析研究
Mizuki Morita,Avsk Mohan Katta,Shandar Ahmad et al.
Mizuki Morita et al.
Background: Protein-lipid interactions play essential roles in the conformational stability and biological functions of membrane proteins. However, few of the previous computational studies have taken into account the ato...
Stability of double-stranded oligonucleotide DNA with a bulged loop: a microarray study [0.03%]
寡核苷酸DNA凸环双链稳定性的微阵列研究
Christian Trapp,Marc Schenkelberger,Albrecht Ott
Christian Trapp
Background: DNA is a carrier of biological information. The hybridization process, the formation of the DNA double-helix from single-strands with complementary sequences, is important for all living cells. DNA microarrays...
Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding [0.03%]
结合配体耗竭和非特异性结合表征α4β2烟碱乙酰胆碱受体的低亲和力Epibatidine结合位点
Alexandra M Person,Gregg B Wells
Alexandra M Person
Background: Along with high affinity binding of epibatidine (Kd1≈10 pM) to α4β2 nicotinic acetylcholine receptor (nAChR), low affinity binding of epibatidine (Kd2≈1-10 nM) to an independent binding site has been repor...
Spindles and active vortices in a model of confined filament-motor mixtures [0.03%]
封闭式(filament-motor)混合物模型中的纺锤体和活性漩涡
David A Head,Wj Briels,Gerhard Gompper
David A Head
Background: Robust self-organization of subcellular structures is a key principle governing the dynamics and evolution of cellular life. In fission yeast cells undergoing division, the mitotic spindle spontaneously emerge...
Introduction of non-linear elasticity models for characterization of shape and deformation statistics: application to contractility assessment of isolated adult cardiocytes [0.03%]
非线性弹性模型引入用于形态和变形统计分析：在成人分离心肌细胞收缩力评估中的应用研究
Carlos Bazan,Trevor Hawkins,David Torres-Barba et al.
Carlos Bazan et al.
Background: We are exploring the viability of a novel approach to cardiocyte contractility assessment based on biomechanical properties of the cardiac cells, energy conservation principles, and information content measure...
Jordan Cates,Garrett C Graham,Natalie Omattage et al.
Jordan Cates et al.
Background: The heat-shock response network controls the adaptation and survival of the cell against environmental stress. This network is highly conserved and is connected with many other signaling pathways. A key elemen...
Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells [0.03%]
细胞外基质密度对贴壁细胞整联蛋白聚集体的大小、形态和位置的概率模型及分析
Erik S Welf,Ulhas P Naik,Babatunde A Ogunnaike
Erik S Welf
Background: Regulation of integrin binding to the specific complementary sites on extra-cellular matrix (ECM) proteins plays a major role in cell adhesion and migration. In addition to regulating single integrin-ligand bo...
Detection and differentiation of bacterial spores in a mineral matrix by Fourier transform infrared spectroscopy (FTIR) and chemometrical data treatment [0.03%]
傅立叶变换红外光谱结合化学计量数据分析在矿物基质中细菌孢子的检测及区分
Andrea Brandes Ammann,Helmut Brandl
Andrea Brandes Ammann
Background: Fourier transform infrared spectroscopy (FTIR) has been used as analytical tool in chemistry for many years. In addition, FTIR can also be applied as a rapid and non-invasive method to detect and identify micr...