Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase [0.03%]
RNA聚合酶催化和转录循环的分子动力学和突变分析
Maria L Kireeva,Kristopher Opron,Steve A Seibold et al.
Maria L Kireeva et al.
Background: During elongation, multi-subunit RNA polymerases (RNAPs) cycle between phosphodiester bond formation and nucleic acid translocation. In the conformation associated with catalysis, the mobile "trigger loop" of ...
Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII [0.03%]
人源碳酸酐酶十三与乙氧基唑胺抑制剂结合的固有热动力学
Lina Baranauskienė,Daumantas Matulis
Lina Baranauskienė
Background: Human carbonic anhydrases (CAs) play crucial role in various physiological processes including carbon dioxide and hydrocarbon transport, acid homeostasis, biosynthetic reactions, and various pathological proce...
Can dietary fibre help provide safer food products for sufferers of gluten intolerance? A well-established biophysical probe may help towards providing an answer [0.03%]
膳食纤维能帮助提供更安全的无麸质食品吗？一种成熟的生物物理检测手段提供了可能的答案
M Samil Kök,Richard Gillis,Shirley Ang et al.
M Samil Kök et al.
Gluten intolerance is a condition which affects an increasing percentage of the world's population and for which the only current treatment is a restrictive gluten free diet. However could the inclusion of a particular polysaccharide, or bl...
DelPhi: a comprehensive suite for DelPhi software and associated resources [0.03%]
DelPhi：一个全面的DelPhi软件及其相关资源套装
Lin Li,Chuan Li,Subhra Sarkar et al.
Lin Li et al.
Background: Accurate modeling of electrostatic potential and corresponding energies becomes increasingly important for understanding properties of biological macromolecules and their complexes. However, this is not an eas...
Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation [0.03%]
表皮生长因子刺激下细胞迁移速度的差异由粘附和突起性质的差异导致
Yue Hou,Sarah Hedberg,Ian C Schneider
Yue Hou
Background: Cell migration plays an essential role in many biological processes, such as cancer metastasis, wound healing and immune response. Cell migration is mediated through protrusion and focal adhesion (FA) assembly...
Arbitrary protein-protein docking targets biologically relevant interfaces [0.03%]
任意的蛋白质对接靶向生物相关的界面
Juliette Martin,Richard Lavery
Juliette Martin
Background: Protein-protein recognition is of fundamental importance in the vast majority of biological processes. However, it has already been demonstrated that it is very hard to distinguish true complexes from false co...
Hédi A Soula,Antoine Coulon,Guillaume Beslon
Hédi A Soula
Background: In the classical view, cell membrane proteins undergo isotropic random motion, that is a 2D Brownian diffusion that should result in an homogeneous distribution of concentration. It is, however, far from the r...
Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane [0.03%]
双苯乙烯基己三烯及其三甲基铵衍生物在液态二棕榈酰磷脂酰胆碱脂质体中的荧光各向异性：异氟烷的相反反应
Steven C Nelson,Steven K Neeley,Eric D Melonakos et al.
Steven C Nelson et al.
Background: The mechanism of action of volatile general anesthetics has not yet been resolved. In order to identify the effects of isoflurane on the membrane, we measured the steady-state anisotropy of two fluorescent pro...
APM_GUI: analyzing particle movement on the cell membrane and determining confinement [0.03%]
APM_GUI：分析细胞膜上颗粒运动并确定其受限状态
Silvia A Menchón,Mauricio G Martín,Carlos G Dotti
Silvia A Menchón
Background: Single-particle tracking is a powerful tool for tracking individual particles with high precision. It provides useful information that allows the study of diffusion properties as well as the dynamics of moveme...
Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties [0.03%]
基于gp120 V3环静电特性的HIV-1亚型聚类分析
Aliana López de Victoria,Chris A Kieslich,Apostolos K Rizos et al.
Aliana López de Victoria et al.
Background: The V3 loop of the glycoprotein gp120 of HIV-1 plays an important role in viral entry into cells by utilizing as coreceptor CCR5 or CXCR4, and is implicated in the phenotypic tropisms of HIV viruses. It has be...