Stochastic dynamics of virus capsid formation: direct versus hierarchical self-assembly [0.03%]
病毒衣壳形成 stochastic 动力学：直接自组装和分层自组装
Johanna E Baschek,Heinrich C R Klein,Ulrich S Schwarz
Johanna E Baschek
Background: In order to replicate within their cellular host, many viruses have developed self-assembly strategies for their capsids which are sufficiently robust as to be reconstituted in vitro. Mathematical models for v...
Jean Marc Victor,Jordanka Zlatanova,Maria Barbi et al.
Jean Marc Victor et al.
Background: Understanding the mechanical properties of chromatin is an essential step towards deciphering the physical rules of gene regulation. In the past ten years, many single molecule experiments have been carried ou...
Two-photon time-lapse microscopy of BODIPY-cholesterol reveals anomalous sterol diffusion in chinese hamster ovary cells [0.03%]
双光子长时间显微镜观察BODIPY-胆固醇在中国仓鼠卵巢细胞中表现出异常的甾醇扩散现象
Frederik W Lund,Michael A Lomholt,Lukasz M Solanko et al.
Frederik W Lund et al.
Background: Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast,...
Hierarchical super-structure identified by polarized light microscopy, electron microscopy and nanoindentation: Implications for the limits of biological control over the growth mode of abalone sea shells [0.03%]
偏光显微镜、电子显微镜和纳米压痕技术鉴定的层次超结构：对鲍鱼海贝壳生长方式的生物限制的影响
Andreas S Schneider,Birgit Heiland,Nicolas J Peter et al.
Andreas S Schneider et al.
Background: Mollusc shells are commonly investigated using high-resolution imaging techniques based on cryo-fixation. Less detailed information is available regarding the light-optical properties. Sea shells of Haliotis p...
Robert G Endres
Robert G Endres
Advances in computational biology allow systematic investigations to ascertain whether internal chemical gradients can be maintained in bacteria - an open question at the resolution limit of fluorescence microscopy. While it was previously ...
Editorial
BMC biophysics. 2012 Sep 7:5:18. DOI:10.1186/2046-1682-5-18 2012
Physical constraints on the establishment of intracellular spatial gradients in bacteria [0.03%]
物理限制对细菌细胞内空间梯度建立的影响
Carolina Tropini,Naveed Rabbani,Kerwyn Casey Huang
Carolina Tropini
Background: Bacteria dynamically regulate their intricate intracellular organization involving proteins that facilitate cell division, motility, and numerous other processes. Consistent with this sophisticated organizatio...
Effects of spermine NONOate and ATP on the thermal stability of hemoglobin [0.03%]
精胺NONO酸和ATP对血红蛋白热稳定影响的研究
Rasha Bassam,Juergen Hescheler,Ayseguel Temiz-Artmann et al.
Rasha Bassam et al.
Background: Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically ac...
Flexibility of EF-hand motifs: structural and thermodynamic studies of Calcium Binding Protein-1 from Entamoeba histolytica with Pb2+, Ba2+, and Sr2+ [0.03%]
EF手征模体的灵活性：来自Entamoeba histolytica的钙结合蛋白-1与Pb2 +，Ba2 +和Sr2 +的结构和热力学研究
Shivesh Kumar,Ejaz Ahmad,Sanjeev Kumar et al.
Shivesh Kumar et al.
Background: EF-hand proteins can be activated by the binding of various heavy metals other than calcium, and such complexes can disturb the calcium-signaling pathway and cause toxicity and disease causing state. So far, n...
Molecular dynamics simulations on aqueous two-phase systems - Single PEG-molecules in solution [0.03%]
溶液中单个PEG分子的分子动力学模拟-AQTPS的研究
Stefan A Oelmeier,Florian Dismer,Jürgen Hubbuch
Stefan A Oelmeier
Background: Molecular Dynamics (MD) simulations are a promising tool to generate molecular understanding of processes related to the purification of proteins. Polyethylene glycols (PEG) of various length are commonly used...
A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors [0.03%]
基于G蛋白偶联受体的多序列和结构分析鉴定与最小配体结合袋相关的相关突变网络
Subhodeep Moitra,Kalyan C Tirupula,Judith Klein-Seetharaman et al.
Subhodeep Moitra et al.
Background: G protein coupled receptors (GPCRs) are seven helical transmembrane proteins that function as signal transducers. They bind ligands in their extracellular and transmembrane regions and activate cognate G prote...