Early integration of the individual student in academic activities: a novel classroom concept for graduate education in molecular biophysics and structural biology [0.03%]
早期将学生个体整合进学术活动中：分子生物物理与结构生物学研究生教育中的一种新型课堂理念
Sanford H Leuba,Sean M Carney,Elizabeth M Dahlburg et al.
Sanford H Leuba et al.
Background: A key challenge in interdisciplinary research is choosing the best approach from a large number of techniques derived from different disciplines and their interfaces. ...
Long range Debye-Hückel correction for computation of grid-based electrostatic forces between biomacromolecules [0.03%]
长程德拜-休克尔校正用于生物大分子间网格化静电势计算中的相互作用力计算
Paolo Mereghetti,Michael Martinez,Rebecca C Wade
Paolo Mereghetti
Background: Brownian dynamics (BD) simulations can be used to study very large molecular systems, such as models of the intracellular environment, using atomic-detail structures. Such simulations require strategies to con...
David E Shoup
David E Shoup
Background: The diffusion-limited reaction rate of a uniform spherical reactant is generalized to anisotropic reactivity. Previous work has shown that the protein model of a uniform sphere is unsatisfactory in many cases....
Raman characterization of Avocado Sunblotch viroid and its response to external perturbations and self-cleavage [0.03%]
牛油果太阳斑小因子病毒的拉曼表征及其对外界刺激和自我剪切的响应
Gaston Hui-Bon-Hoa,Hussein Kaddour,Jacques Vergne et al.
Gaston Hui-Bon-Hoa et al.
Background: Viroids are the smallest pathogens of plants. To date the structural and conformational details of the cleavage of Avocado sunblotch viroid (ASBVd) and the catalytic role of Mg2+ ions in efficient self-cleavag...
Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer [0.03%]
探究细胞核纳米尺度结构变化作为癌症早期迹象的研究
Yang Liu,Shikhar Uttam,Sergey Alexandrov et al.
Yang Liu et al.
Background: The cell and tissue structural properties assessed with a conventional bright-field light microscope play a key role in cancer diagnosis, but they sometimes have limited accuracy in detecting early-stage cance...
Bogdan I Costescu,Frauke Gräter
Bogdan I Costescu
Background: Biomolecules or other complex macromolecules undergo conformational transitions upon exposure to an external perturbation such as ligand binding or mechanical force. To follow fluctuations in pairwise forces b...
Improving accuracy of cell and chromophore concentration measurements using optical density [0.03%]
基于光学密度的细胞及色素浓度测定准确性的提高方法研究
John A Myers,Brandon S Curtis,Wayne R Curtis
John A Myers
Background: UV-vis spectrophotometric optical density (OD) is the most commonly-used technique for estimating chromophore formation and cell concentration in liquid culture. OD wavelength is often chosen with little thoug...
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition [0.03%]
分子动力学模拟表明LSD1/CoREST-H3-组蛋白相互识别的诱导契合机制
Nadeem A Vellore,Riccardo Baron
Nadeem A Vellore
Background: Lysine Specific Demethylase (LSD1 or KDM1A) in complex with its co-repressor protein CoREST catalyzes the demethylation of the H3 histone N-terminal tail and is currently one of the most promising epigenetic t...
An exact approach for studying cargo transport by an ensemble of molecular motors [0.03%]
一种用于研究分子马达集合运输负荷的精确方法
Donatello Materassi,Subhrajit Roychowdhury,Thomas Hays et al.
Donatello Materassi et al.
Background: Intracellular transport is crucial for many cellular processes where a large fraction of the cargo is transferred by motor-proteins over a network of microtubules. Malfunctions in the transport mechanism under...
A comparative study of ribosomal proteins: linkage between amino acid distribution and ribosomal assembly [0.03%]
核糖体蛋白的比较研究：氨基酸分布与核糖体装配间的联系
Brittany Burton Lott,Yongmei Wang,Takuya Nakazato
Brittany Burton Lott
Background: Assembly of the ribosome from its protein and RNA constituents must occur quickly and efficiently in order to synthesize the proteins necessary for all cellular activity. Since the early 1960's, certain charac...