A flexible approach to assess fluorescence decay functions in complex energy transfer systems [0.03%]
一种在复杂能量传输系统中评估荧光衰减函数的灵活方法
Christoph Roethlein,Markus S Miettinen,Zoya Ignatova
Christoph Roethlein
Background: Time-correlated Förster resonance energy transfer (FRET) probes molecular distances with greater accuracy than intensity-based calculation of FRET efficiency and provides a powerful tool to study biomolecular...
Richard P Sear,Ignacio Pagonabarraga,Andrew Flaus
Richard P Sear
The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based motor networks and multi-scale c...
Langevin dynamics simulations of charged model phosphatidylinositol lipids in the presence of diffusion barriers: toward an atomic level understanding of corralling of PIP2 by protein fences in biological membranes [0.03%]
带扩散屏障的带电模型磷脂酰肌醇脂质的朗之万动力学模拟：朝向生物膜中PIP2蛋白质栅栏围捕的原子水平理解
Kyu Il Lee,Wonpil Im,Richard W Pastor
Kyu Il Lee
Background: The polyvalent acidic lipid phosphatidylinositol, 4,5-bisphosphate (PIP2) is important for many cellular functions. It has been suggested that different pools of PIP2 exist in the cytoplasmic leaflet of the pl...
Simulation tools for particle-based reaction-diffusion dynamics in continuous space [0.03%]
连续空间中基于粒子的反应扩散动力学仿真工具
Johannes Schöneberg,Alexander Ullrich,Frank Noé
Johannes Schöneberg
Particle-based reaction-diffusion algorithms facilitate the modeling of the diffusional motion of individual molecules and the reactions between them in cellular environments. A physically realistic model, depending on the system at hand an...
Analytical model for macromolecular partitioning during yeast cell division [0.03%]
酵母细胞分裂期间大分子分配的分析模型
Ali Kinkhabwala,Anton Khmelinskii,Michael Knop
Ali Kinkhabwala
Background: Asymmetric cell division, whereby a parent cell generates two sibling cells with unequal content and thereby distinct fates, is central to cell differentiation, organism development and ageing. Unequal partiti...
Hui Ye,Austen Curcuru
Hui Ye
Background: Cells exhibit distortion when exposed to a strong electric field, suggesting that the field imposes control over cellular biomechanics. Closed pure lipid bilayer membranes (vesicles) have been widely used for ...
Drift correction for single-molecule imaging by molecular constraint field, a distance minimum metric [0.03%]
基于分子约束场距离极小度量的单分子图像漂移校正方法
Renmin Han,Liansan Wang,Fan Xu et al.
Renmin Han et al.
Background: The recent developments of far-field optical microscopy (single molecule imaging techniques) have overcome the diffraction barrier of light and improve image resolution by a factor of ten compared with convent...
Xuesi M Shao,Liyo Kao,Ira Kurtz
Xuesi M Shao
Background: The ion transport stoichiometry (q) of electrogenic transporters is an important determinant of their function. q can be determined by the reversal potential (Erev) if the transporter under study is the only e...
The glassy state of crambin and the THz time scale protein-solvent fluctuations possibly related to protein function [0.03%]
玻璃态的crambin及与其功能或许相关的太赫兹时间尺度上的蛋白质-溶剂波动
Kristina N Woods
Kristina N Woods
Background: THz experiments have been used to characterize the picosecond time scale fluctuations taking place in the model, globular protein crambin. Res...
Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and docking [0.03%]
基于隐式溶剂分子动力学模拟和对接的PMX53通过C5aR抑制机制研究
Phanourios Tamamis,Chris A Kieslich,Gregory V Nikiforovich et al.
Phanourios Tamamis et al.
Background: The complement protein C5a acts by primarily binding and activating the G-protein coupled C5a receptor C5aR (CD88), and is implicated in many inflammatory diseases. The cyclic hexapeptide PMX53 (sequence Ace-P...