Lucas C Wheeler,Michael J Harms
Lucas C Wheeler
Background: S100A5 is a calcium binding protein found in a small subset of amniote tissues. Little is known about the biological roles of S100A5, but it may be involved in inflammation and olfactory signaling. Previous wo...
Kinetic and thermodynamic studies reveal chemokine homologues CC11 and CC24 with an almost identical tertiary structure have different folding pathways [0.03%]
动力学和热力学研究揭示化学因子同源物CC11和CC24具有几乎相同的三级结构但具有不同的折叠途径
Baosheng Ge,Xiaoyong Jiang,Yao Chen et al.
Baosheng Ge et al.
Background: Proteins with low sequence identity but almost identical tertiary structure and function have been valuable to uncover the relationship between sequence, tertiary structure, folding mechanism and functions. Tw...
Modeling of RAS complexes supports roles in cancer for less studied partners [0.03%]
模式模拟揭示 Ras 复合物的抗癌作用机制
H Billur Engin,Daniel Carlin,Dexter Pratt et al.
H Billur Engin et al.
Background: RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to ca...
DNA secondary structure formation by DNA shuffling of the conserved domains of the Cry protein of Bacillus thuringiensis [0.03%]
芽孢杆菌苏云金芽胞杆菌Cry蛋白保守区域的DNA镶嵌及二级结构形成研究
Efrain H Pinzon,Daniel A Sierra,Miguel O Suarez et al.
Efrain H Pinzon et al.
Background: The Cry toxins, or δ-endotoxins, are a diverse group of proteins produced by Bacillus thuringiensis. While DNA secondary structures are biologically relevant, it is unknown if such structures are formed in re...
Accuracy of the detection of binding events using 3D single particle tracking [0.03%]
三维单粒子跟踪检测结合事件的准确性
Sara Carozza,Jamie Culkin,John van Noort
Sara Carozza
Background: Nanoparticles can be used as markers to track the position of biomolecules, such as single proteins, inside living cells. The activity of a protein can sometimes be inferred from changes in the mobility of the...
BFPTool: a software tool for analysis of Biomembrane Force Probe experiments [0.03%]
BFPTool：一种用于分析生物膜力探针实验的软件工具
Daniel Šmít,Coralie Fouquet,Mohamed Doulazmi et al.
Daniel Šmít et al.
Background: The Biomembrane Force Probe is an approachable experimental technique commonly used for single-molecule force spectroscopy and experiments on biological interfaces. The technique operates in the range of force...
Native flexibility of structurally homologous proteins: insights from anisotropic network model [0.03%]
结构同源蛋白质的固有柔性：各向异性网络模型的见解
Ranja Sarkar
Ranja Sarkar
Background: Single-molecule microscopic experiments can measure the mechanical response of proteins to pulling forces applied externally along different directions (inducing different residue pairs in the proteins by unia...
Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding [0.03%]
人乳铁蛋白的溶液结构与结构域动力学及铁离子配体结合的影响
Clemens Sill,Ralf Biehl,Bernd Hoffmann et al.
Clemens Sill et al.
Background: Human lactoferrin is an iron-binding protein of the innate immune system consisting of two connected lobes, each with a binding site located in a cleft. The clefts in each lobe undergo a hinge movement from op...
Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking [0.03%]
单分子光学追踪技术研究胆固醇介导的活细胞EGF受体原位相互作用
Chien Y Lin,Jung Y Huang,Leu-Wei Lo
Chien Y Lin
Background: The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in...
Yareni A Ayala,Bruno Pontes,Diney S Ether et al.
Yareni A Ayala et al.
Background: The viscoelastic properties of cells have been investigated by a variety of techniques. However, the experimental data reported in literature for viscoelastic moduli differ by up to three orders of magnitude. ...