Andrew C Miklos,Conggang Li,Courtney D Sorrell et al.
Andrew C Miklos et al.
Background: Solutions containing high macromolecule concentrations are predicted to affect a number of protein properties compared to those properties in dilute solution. In cells, these macromolecular crowders have a lar...
Mechanism of PhosphoThreonine/Serine Recognition and Specificity for Modular Domains from All-atom Molecular Dynamics [0.03%]
模块化结构域对磷酸胸苷/丝氨酸的识别机制及其特异性——全原子分子动力学研究
Yu-Ming M Huang,Chia-En A Chang
Yu-Ming M Huang
Background: Phosphopeptide-binding domains mediate many vital cellular processes such as signal transduction and protein recognition. We studied three well-known domains important for signal transduction: BRCT repeats, WW...
Many-particle Brownian and Langevin Dynamics Simulations with the Brownmove package [0.03%]
Brownmove包的多粒子布朗和兰格文动力学模拟
Tihamér Geyer
Tihamér Geyer
Background: Brownian Dynamics (BD) is a coarse-grained implicit-solvent simulation method that is routinely used to investigate binary protein association dynamics, but due to its efficiency in handling large simulation v...
Ai Díez,A Ortega,J Garcia de la Tore
Ai Díez
Background: We have devised a protocol for the Brownian dynamics simulation of an analytical ultracentrifugation experiment that allows for an accurate and efficient prediction of the time-dependent concentration profiles...
A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction [0.03%]
可解的模型在突触连接中神经递质的扩散和反应
Jorge L Barreda,Huan-Xiang Zhou
Jorge L Barreda
Background: The diffusion and reaction of the transmitter acetylcholine in neuromuscular junctions and the diffusion and binding of Ca2+ in the dyadic clefts of ventricular myocytes have been extensively modeled by Monte ...
J Andrew McCammon
J Andrew McCammon
The binding and active sites of proteins are often dynamically occluded by motion of the nearby polypeptide. A variety of theoretical and computational methods have been developed to predict rates of ligand binding and reactivity in such ca...
Diffusion in crowded biological environments: applications of Brownian dynamics [0.03%]
封闭生物环境中的扩散：Brown运动的应用
Maciej Długosz,Joanna Trylska
Maciej Długosz
Biochemical reactions in living systems occur in complex, heterogeneous media with total concentrations of macromolecules in the range of 50 - 400 mgml. Molecular species occupy a significant fraction of the immersing medium, up to 40% of v...
Diffusion and association processes in biological systems: theory, computation and experiment [0.03%]
生物系统中的扩散和缔合过程：理论、计算与实验
Paolo Mereghetti,Daria Kokh,J Andrew McCammon et al.
Paolo Mereghetti et al.
Macromolecular diffusion plays a fundamental role in biological processes. Here, we give an overview of recent methodological advances and some of the challenges for understanding how molecular diffusional properties influence biological fu...
New horizons in Biophysics [0.03%]
生物物理新视野
Elizabeth C Moylan
Elizabeth C Moylan
This editorial celebrates the re-launch of PMC Biophysics previously published by PhysMath Central, in its new format as BMC Biophysics published by BioMed Central with an expanded scope and Editorial Board. BMC Biophysics will fill its own...
Thermotropic phase behavior and headgroup interactions of the nonbilayer lipids phosphatidylethanolamine and monogalactosyldiacylglycerol in the dry state [0.03%]
磷脂酰乙醇胺和单半乳糖基二酰glycerol的非双层膜脂质的热致异相行为及头部组相互作用（干态）
Antoaneta V Popova,Dirk K Hincha
Antoaneta V Popova
Background: Although biological membranes are organized as lipid bilayers, they contain a substantial fraction of lipids that have a strong tendency to adopt a nonlamellar, most often inverted hexagonal (HII) phase. The p...