Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide [0.03%]
分子氢通过清除过量的一氧化氮衍生的过氧亚硝酸盐间接保护软骨细胞并影响基因表达
Teruyasu Hanaoka,Naomi Kamimura,Takashi Yokota et al.
Teruyasu Hanaoka et al.
Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remai...
RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation [0.03%]
BACE和APP的RNA干扰沉默能减弱异氟醚诱导的半胱天冬酶活化
Yuanlin Dong,Zhipeng Xu,Yiying Zhang et al.
Yuanlin Dong et al.
Background: β-Amyloid protein (Aβ) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Aβ levels can attenuat...
James Toole
James Toole
This is an editorial for the inauguration of the Medical Gas Research and addresses a particular issue of using hyperbaric oxygen for stroke treatment.
Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: two case reports [0.03%]
高压氧治疗（1.5ATA）在运动相关性TBI/CSTE治疗中的应用：两例报告
Kenneth P Stoller
Kenneth P Stoller
Despite adequate evidence, including randomized controlled trials; hyperbaric oxygen is not yet recognized as efficacious for treating various forms of brain injury, specifically traumatic brain injury. Political-economic issues have kept t...
Effect of an hyperbaric nitrogen narcotic ambience on arginine and citrulline levels, the precursor and co-product of nitric oxide, in rat striatum [0.03%]
高压氮麻醉对纹状体一氧化氮前体物质和伴生产物精氨酸和瓜氨酸水平的影响
Nicolas Vallée,Jean-Jacques Rissoe,Jean-Eric Blatteau
Nicolas Vallée
Previous studies performed in the laboratory have shown that nitrogen narcosis induces a decrease in striatal glutamate and dopamine levels. Although we stimulated the N-methyl-D-aspartate (NMDA) receptor, an important glutamate receptor re...
Emergent role of gasotransmitters in ischemia-reperfusion injury [0.03%]
一氧化氮、硫化氢和二氧化氮等气态信号分子在缺血再灌注损伤中的作用不容忽视
Bridgette F Moody,John W Calvert
Bridgette F Moody
Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are lipid-soluble, endogenously produced gaseous messenger molecules collectively known as gasotransmitters. Over the last several decades, gasotransmitters have emerged as ...
Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model [0.03%]
氢盐水通过减少氧化应激对局灶性脑缺血再灌注损伤发挥神经保护作用
Ying Liu,Wenwu Liu,Xuejun Sun et al.
Ying Liu et al.
Hydrogen gas is neuroprotective in cerebral ischemia animal models. In this study, we tested the neuroprotective effects of hydrogen saline, which is safe and easy to use clinically, in a rat model of middle cerebral artery occlusion (MCAO)...
Property value estimation for inhaled therapeutic binary gas mixtures: He, Xe, N2O, and N2 with O2 [0.03%]
二元气体混合物(O₂与He、N₂O、N₂和Xe)吸入治疗价值评估
Ira Katz,Georges Caillibotte,Andrew R Martin et al.
Ira Katz et al.
Background: The property values of therapeutic gas mixtures are important in designing devices, defining delivery parameters, and in understanding the therapeutic effects. In the medical related literature the vast majori...
Jun Mu,Paul R Krafft,John H Zhang
Jun Mu
Neurogenesis in adults, initiated by injury to the central nervous system (CNS) presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT) enhances neurogenesis which accordingly may improve functio...
Isoflurane does not cause neuroapoptosis but reduces astroglial processes in young adult mice [0.03%]
异氟醚不会导致神经凋亡但会减少年轻成年小鼠的星形胶质细胞突进程
Renee M Dallasen,James D Bowman,Yan Xu
Renee M Dallasen
Background: Isoflurane, a volatile anesthetic widely used clinically, has been implicated to be both neuroprotective and neurotoxic. The claim about isoflurane causing neural apoptosis remains controversial. In this study...