RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA [0.03%]
RhoB通过负调控RhoA在一定程度上控制内皮细胞的形态发生
Grant A Howe,Christina L Addison
Grant A Howe
Recent studies have suggested a role for the small GTPase RhoB in the control of processes required for angiogenesis. However, the mechanisms whereby RhoB exerts control over these processes are not well understood. Given the role of vascul...
Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion [0.03%]
淋巴增强结合因子1是脊椎动物特有的Lef1/Tcf1亚家族的代表，它是人内皮细胞中Wnt-β-catenin信号通路的靶基因并调节基质金属蛋白酶-2的表达促进内皮细胞侵袭
Marina Planutiene,Kestutis Planutis,Randall F Holcombe
Marina Planutiene
Background: Wnt signaling is activated in many types of cancer and normal physiological processes. Various Wnt-related secreted factors may influence angiogenesis both in the tumor microenvironment and in normal tissues b...
Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization [0.03%]
视网膜细胞和内皮细胞的共培养诱导视网膜新生血管的关键基因表达调控
Ravindra Kumar,Sandra Harris-Hooker,Ritesh Kumar et al.
Ravindra Kumar et al.
Background: Neovascularization (angiogenesis) is a multistep process, controlled by opposing regulatory factors, which plays a crucial role in several ocular diseases. It often results in vitreous hemorrhage, retinal deta...
Nanoparticle mediated targeting of VEGFR and cancer stem cells for cancer therapy [0.03%]
纳米颗粒介导的靶向VEGFR和癌症干细胞的癌症疗法
Rashmi K Ambasta,Archita Sharma,Pravir Kumar
Rashmi K Ambasta
Angiogenesis is a crucial process in tumor pathogenesis as it sustains malignant cells with nutrients and oxygen. It is well known that tumor cells secrete various growth factors, including VEGF, which triggers endothelial cells to form new...
The role of microRNAs in neural stem cell-supported endothelial morphogenesis [0.03%]
微小核糖核酸在神经干细胞支持的内皮发生中的作用
Tamara Roitbak,Olga Bragina,Jamie L Padilla et al.
Tamara Roitbak et al.
Functional signaling between neural stem/progenitor cells (NSPCs) and brain endothelial cells (ECs) is essential to the coordination of organized responses during initial embryonic development and also during tissue repair, which occurs fol...
Application of microtechnologies for the vascularization of engineered tissues [0.03%]
微技术在组织工程血管化中的应用研究进展
Robert Gauvin,Maxime Guillemette,Mehmet Dokmeci et al.
Robert Gauvin et al.
Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The f...
Challenges in translating vascular tissue engineering to the pediatric clinic [0.03%]
血管组织工程在儿科临床应用的挑战
Daniel R Duncan,Christopher K Breuer
Daniel R Duncan
The development of tissue-engineered vascular grafts for use in cardiovascular surgery holds great promise for improving outcomes in pediatric patients with complex congenital cardiac anomalies. Currently used synthetic grafts have a number...
Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor [0.03%]
环氧化酶-2抑制可减少血管内皮生长因子阻断过程中的肿瘤转移和炎性信号转导
Jason C Fisher,Jeffrey W Gander,Mary Jo Haley et al.
Jason C Fisher et al.
Vascular endothelial growth factor (VEGF) blockade is an effective therapy for human cancer, yet virtually all neoplasms resume primary tumor growth or metastasize during therapy. Mechanisms of progression have been proposed to include gene...
Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells [0.03%]
cyclic应变上调VEGF并抑制血管平滑肌细胞增殖
Joseph F Schad,Kate R Meltzer,Michael R Hicks et al.
Joseph F Schad et al.
Objective: Vascular smooth muscle cell (VSMC) hypertrophy and proliferation occur in response to strain-induced local and systemic inflammatory cytokines and growth factors which may contribute to hypertension, atheroscle...
Dll4-Notch signaling as a therapeutic target in tumor angiogenesis [0.03%]
Dll4-notch信号通路在肿瘤血管生成治疗中的作用
Frank Kuhnert,Jessica R Kirshner,Gavin Thurston
Frank Kuhnert
Tumor angiogenesis is an important target for cancer therapy, with most current therapies designed to block the VEGF signaling pathway. However, clinical resistance to anti-VEGF therapy highlights the need for targeting additional tumor ang...