Human and mouse brain-derived endothelial cells require high levels of growth factors medium for their isolation, in vitro maintenance and survival [0.03%]
人和小鼠脑源性内皮细胞的分离、体外培养和存活需要高水平的生长因子介质
Stefania Elena Navone,Giovanni Marfia,Sara Nava et al.
Stefania Elena Navone et al.
Background: Brain microvascular endothelial cells (BMVECs) constitute the primary limitation for passage of ions and molecules from the blood into the brain through the blood brain barrier. Numerous multi-step procedures ...
EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression [0.03%]
表没食子儿茶素没食子酸酯通过抑制缺氧诱导因子-1α和NFκB的活化及VEGF表达而阻抑乳腺肿瘤血管生成及其生长
Jian-Wei Gu,Kristina L Makey,Kevan B Tucker et al.
Jian-Wei Gu et al.
The role of EGCG, a major green tea catechin in breast cancer therapy is poorly understood. The present study tests the hypothesis that EGCG can inhibit the activation of HIF-1α and NFκB, and VEGF expression, thereby suppressing tumor ang...
Vascular endothelial growth factor-B expression in postischemic rat brain [0.03%]
缺血大鼠脑内血管内皮生长因子-B的表达
Lin Xie,Xiaoou Mao,Kunlin Jin et al.
Lin Xie et al.
Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. ...
Maria José Costa,Xiaoqing Wu,Henar Cuervo et al.
Maria José Costa et al.
Background: Notch4 is a member of the Notch family of receptors that is primarily expressed in the vascular endothelial cells. Genetic deletion of Notch4 does not result in an overt phenotype in mice, thus the function of...
Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells [0.03%]
基因表达分析揭示了婴幼儿血管瘤内皮细胞转录组与正常皮肤微血管内皮细胞的明显差异
Jessica M Stiles,Rebecca K Rowntree,Clarissa Amaya et al.
Jessica M Stiles et al.
Background: Infantile hemangiomas are benign vascular tumors primarily found on the skin in 10% of the pediatric population. The etiology of this disease is largely unknown and while large scale genomic studies have exami...
Correlation of tumor-associated macrophages and clinicopathological factors in Wilms tumor [0.03%]
肿瘤相关巨噬细胞与肾母细胞瘤临床病理因素相关性分析
Peter Liou,Leah Bader,Antai Wang et al.
Peter Liou et al.
Background/purpose: Despite high long-term survival rates in patients with Wilms tumor, there is a need to develop better prognostic biomarkers in order to maximize cure while avoiding treatment-associated morbidities. Tu...
The importance of microglia in the development of the vasculature in the central nervous system [0.03%]
微胶质细胞在中枢神经系统血管发育中的重要作用
Tom Arnold,Christer Betsholtz
Tom Arnold
The body's vascular system is thought to have developed in order to supply oxygen and nutrients to cells beyond the reach of simple diffusion. Hence, relative hypoxia in the growing central nervous system (CNS) is a major driving force for ...
The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients [0.03%]
缺血性卒中患者循环内皮祖细胞的血管新生基因谱式研究
Míriam Navarro-Sobrino,Mar Hernández-Guillamon,Israel Fernandez-Cadenas et al.
Míriam Navarro-Sobrino et al.
Background: The identification of circulating endothelial progenitor cells (EPCs) has introduced new possibilities for cell-based treatments for stroke. We tested the angiogenic gene expression of outgrowth endothelial ce...
Sudarshan Anand
Sudarshan Anand
Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, in...
Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect [0.03%]
关于颌骨坏死(BRONJ)的诊断标准及其可能的发生机制——意想不到的抗血管生成副作用
Dileep Sharma,Saso Ivanovski,Mark Slevin et al.
Dileep Sharma et al.
Recently, bisphosphonates (BPs) have been widely used in medical practice as anti-resorptive agents owing to their anti-osteoclatic action. In addition, these compounds are also used for their analgesic action and their potential anti-tumou...