Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression [0.03%]
血管肉瘤细胞中由高CSF-1R表达标记的药物抵抗性的药物蓄积溶酶体机制
Brandi H Gorden,Jhuma Saha,Ali Khammanivong et al.
Brandi H Gorden et al.
Background: Human angiosarcoma and canine hemangiosarcoma are thought to arise from vascular tissue or vascular forming cells based upon their histological appearance. However, recent evidence indicates a hematopoietic or...
Ageing and microvasculature [0.03%]
衰老与微血管系统
Maria Giovanna Scioli,Alessandra Bielli,Gaetano Arcuri et al.
Maria Giovanna Scioli et al.
A decline in the function of the microvasculature occurs with ageing. An impairment of endothelial properties represents a main aspect of age-related microvascular alterations. Endothelial dysfunction manifests itself through a reduced angi...
Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage [0.03%]
一种针对VEGFR/FGFR的抗血管生成药物仑伐替尼在人源肿瘤异种移植瘤模型中显示出广谱的抗肿瘤活性且与微血管密度和周细胞覆盖相关
Yuji Yamamoto,Junji Matsui,Tomohiro Matsushima et al.
Yuji Yamamoto et al.
Background: Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs) targeting vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet growth facto...
Evaluation of side effects of radiofrequency capacitive hyperthermia with magnetite on the blood vessel walls of tumor metastatic lesion surrounding the abdominal large vessels: an agar phantom study [0.03%]
磁性容积电热对腹主动脉旁肿瘤转移灶血管壁副作用的评价：琼脂模型研究
Noriyasu Kawai,Daichi Kobayashi,Takahiro Yasui et al.
Noriyasu Kawai et al.
Background: Magnetite used in an 8-MHz radiofrequency (RF) capacitive heating device can increase the temperature of a specific site up to 45°C. When treating a metastatic lesion around large abdominal vessels via hypert...
Limitations of the dorsal skinfold window chamber model in evaluating anti-angiogenic therapy during early phase of angiogenesis [0.03%]
有关抗血管生成疗法评价的背囊模型的局限性：血管生成早期阶段方面的研究
Nikolett M Biel,Jennifer A Lee,Brian S Sorg et al.
Nikolett M Biel et al.
Background: Angiogenesis is an essential process during tumor development and growth. The murine dorsal skinfold window chamber model has been used for the study of both tumor microvasculature and other vascular diseases,...
VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment [0.03%]
血管内皮生长因子受体-1阻断可破坏着床后子宫蜕膜血管生成和巨噬细胞募集
Nataki C Douglas,Ralf C Zimmermann,Qian Kun Tan et al.
Nataki C Douglas et al.
Background: Angiogenesis and macrophage recruitment to the uterus are key features of uterine decidualization; the progesterone-mediated uterine changes that allow for embryo implantation and initiation of pregnancy. In t...
In vitro pre-vascularisation of tissue-engineered constructs A co-culture perspective [0.03%]
组织工程构建体的体外预先血管化共培养观点
Jeremy Baldwin,Mélanie Antille,Ulrich Bonda et al.
Jeremy Baldwin et al.
In vitro pre-vascularization is one of the main vascularization strategies in the tissue engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to implantation provides researchers with a greater degree of contr...
Yingdi Wang,Michael Simons
Yingdi Wang
The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including con...
Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cells [0.03%]
一种新型环状RGD肽模拟物对人内皮细胞增殖、迁移和血管生成活性的影响
Roberto Fanelli,Laura Schembri,Umberto Piarulli et al.
Roberto Fanelli et al.
Background: Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are a novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since integrins are a promising target for the mod...
Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells [0.03%]
索坦抑制三阴性乳腺癌的增殖、迁移、抗凋亡、肿瘤血管生成和生长，但可增加乳腺癌干细胞的比例
Edmund Chinchar,Kristina L Makey,John Gibson et al.
Edmund Chinchar et al.
The majority of triple-negative breast cancers (TNBCs) are basal-like breast cancers. However there is no reported study on anti-tumor effects of sunitinib in xenografts of basal-like TNBC (MDA-MB-468) cells. In the present study, MDA-MB-23...