The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells [0.03%]
AMP活化蛋白激酶在血管内皮生长因子A和B对人主动脉内皮细胞功能效应中的作用
James A Reihill,Marie-Ann Ewart,Ian P Salt
James A Reihill
Background: Vascular endothelial growth factors (VEGFs) are key regulators of endothelial cell function and angiogenesis. We and others have previously demonstrated that VEGF-A stimulates AMP-activated protein kinase (AMP...
Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective [0.03%]
纳米技术在冠状动脉内支架再狭窄治疗中的临床应用展望
Garry McDowell,Mark Slevin,Jerzy Krupinski
Garry McDowell
Coronary in stent restenosis remains a significant limitation to the long term efficacy of coronary artery stent placement. In this review the authors review the pathophysiology of coronary in stent restenosis, together with an overview of ...
Agata Matejuk,Qixin Leng,Szu-Ting Chou et al.
Agata Matejuk et al.
Angiogenesis has a critical role in physiologic and disease processes. For the growth of tumors, angiogenesis must occur to carry sufficient nutrients to the tumor. In addition to growth, development of new blood vessels is necessary for in...
Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis [0.03%]
血管内皮细胞VE-钙黏蛋白及基质金属蛋白酶表达变化及其对血管生成的影响
Manikantan S Kiran,Raveendran I Viji,Sameer Vb Kumar et al.
Manikantan S Kiran et al.
The mechanism of cell-cell contact dependent regulation of pericellular proteolysis in angiogenesis was examined by studying the expression of MMPs using isolated HUVECs in culture. Zymography, Immunoblot and RT-PCR analysis showed that the...
Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential [0.03%]
真皮成纤维细胞表现出与脂肪来源的间充质干细胞相似的表型和分化能力，但在抗炎和促血管生成潜能方面不同
Antonella Blasi,Carmela Martino,Luigi Balducci et al.
Antonella Blasi et al.
Background: Mesenchymal stem cells (MSCs) are multipotent stem cells able to differentiate into different cell lineages. However, MSCs represent a subpopulation of a more complex cell composition of stroma cells contained...
Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo [0.03%]
体外和体内血管内皮细胞的血管生成作用及血小板衍生提取物的互补效应
Mark Roedersheimer,Hala Nijmeh,Nana Burns et al.
Mark Roedersheimer et al.
Background: Platelets contribute to vascular homeostasis and angiogenesis through the release of multiple growth factors, cytokines and nucleotides, such as ATP and ADP. Recent reports have demonstrated a marked growth-pr...
Deboshri Banerjee,Rania Harfouche,Shiladitya Sengupta
Deboshri Banerjee
Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology to improve the pharmac...
Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity [0.03%]
诺特定调血管内皮细胞中基质金属蛋白酶活性以调节VEGF的作用
Yasuhiro Funahashi,Carrie J Shawber,Anshula Sharma et al.
Yasuhiro Funahashi et al.
Background: In the vasculature, Notch signaling functions as a downstream effecter of Vascular Endothelial Growth Factor (VEGF) signaling. VEGF regulates sprouting angiogenesis in part by inducing and activating matrix me...
Jan Kitajewski,Yihai Cao,Mark Slevin
Jan Kitajewski