Omotinuwe Adepoju,Alvin Wong,Alex Kitajewski et al.
Omotinuwe Adepoju et al.
Background: Infantile hemangiomas (IHs) are the most common benign tumor of infancy, yet their pathogenesis is poorly understood. IHs are believed to originate from a progenitor cell, the hemangioma stem cell (HemSC). Rec...
Austin Gurney,Timothy Hoey
Austin Gurney
DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of t...
Minhong Yan
Minhong Yan
DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chro...
Phase I study of telatinib (BAY 57-9352): analysis of safety, pharmacokinetics, tumor efficacy, and biomarkers in patients with colorectal cancer [0.03%]
Telatinib（BAY 57-9352）Ⅰ期临床研究：胶质瘤患者的安全性、药代动力学、肿瘤疗效和生物标记物分析
Klaus Mross,Annette Frost,Max E Scheulen et al.
Klaus Mross et al.
Background: Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. ...
Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis [0.03%]
可溶性血管内皮生长因子受体1的自分泌活性调控血管内皮细胞功能和血管生成
Shakil Ahmad,Peter W Hewett,Bahjat Al-Ani et al.
Shakil Ahmad et al.
Background: The negative feedback system is an important physiological regulatory mechanism controlling angiogenesis. Soluble vascular endothelial growth factor (VEGF) receptor-1 (sFlt-1), acts as a potent endogenous solu...
Effects on duration of post-operative ischemia and patterns of blood flow recovery in different conditions of mouse hind limb ischemia [0.03%]
不同条件下小鼠后肢缺血手术后缺血持续时间及血液恢复模式的影响研究
Husain A Al-Mubarak,Talal M Alamri,Saif A Aljabab et al.
Husain A Al-Mubarak et al.
Background: Current limitations to the experimentation on patients with peripheral arterial disease push the development of different preclinical strategies. We investigated both duration of ischemia and blood flow recove...
Insulin-Like Growth Factor-1 (IGF-1) Reduces ischemic changes and increases circulating angiogenic factors in experimentally - induced myocardial infarction in rats [0.03%]
胰岛素样生长因子-1(IGF-1)减少实验性诱导的大鼠心肌梗死的缺血改变和增加循环血管生成因子
Mathews Lisa,Nagaraja Haleagrahara,Srikumar Chakravarthi
Mathews Lisa
Background: Coronary artery disease is a global health concern in the present day with limited therapies. Extensive efforts have been devoted to find molecular therapies to enhance perfusion and function of the ischemic m...
Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2 [0.03%]
3-氨基苯甲酰胺通过调节尿激酶型纤溶酶原激活物和基质金属蛋白酶2的表达刺激低剂量血管生成作用研究
Riccardo Caldini,Elena Fanti,Lucia Magnelli et al.
Riccardo Caldini et al.
Background: Poly(ADP-Ribose) polymerase (PARP) activity has been demonstrated fundamental in many cellular processes, including DNA repair, cell proliferation and differentiation. In particular, PARP activity has been rec...
Angiogenic potential of endothelial progenitor cells and embryonic stem cells [0.03%]
内皮干细胞和胚胎干细胞的血管生成潜能
Peter C Rae,Richard Dw Kelly,Stuart Egginton et al.
Peter C Rae et al.
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis. However, current angiogenic therapies involving EPC tra...
A deficiency of uPAR alters endothelial angiogenic function and cell morphology [0.03%]
uPAR缺乏影响内皮细胞的血管生成功能和细胞形态
Rashna D Balsara,Reid Merryman,Farhaad Virjee et al.
Rashna D Balsara et al.
The angiogenic potential of a cell requires dynamic reorganization of the cytoskeletal architecture that involves the interaction of urokinase-type plasminogen activator receptor (uPAR) with the extracellular matrix. This study focuses on t...