Advances in the Gut-Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential [0.03%]
肠道-肺轴及支气管哮喘的研究进展：从机制到治疗潜力
Ting Zheng,Yi Huang,Hongmei Yao
Ting Zheng
Background: Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advanceme...
Evaluating Generative AI Large Language Models for Urticaria Management: A Comparative Analysis of DeepSeek-R1 and ChatGPT-4o [0.03%]
用于荨麻疹管理的生成式AI大型语言模型评估：DeepSeek-R1和ChatGPT-4o比较分析
Mengyao Yang,Jingchen Liang,Luyue Zhang et al.
Mengyao Yang et al.
Introduction: Urticaria is a prevalent condition affecting a significant portion of the global population. Both dermatologists and patients require access to up-to-date and accurate information. Traditional search engines...
Efficacy and Safety of Stapokibart in Adults With Moderate-to-Severe Atopic Dermatitis With and Without Type 2 Comorbidities: A Post Hoc Analysis of a Phase 3 Trial [0.03%]
针对伴或不伴2型合并症的中重度特应性皮炎成人患者的斯妥昔巴利疗效和安全性：来自一项3期试验的事后分析
Yan Zhao,Litao Zhang,Liming Wu et al.
Yan Zhao et al.
Background: Atopic dermatitis (AD) often coexists with other type 2 inflammatory diseases. Stapokibart, a humanized IgG4 monoclonal antibody targeting interleukin-4 receptor alpha subunit, showed high efficacy and favorab...
Variability of Diagnostic Outcomes in Nasal Allergen Challenge: The Role of Combined Subjective and Objective Indicators [0.03%]
鼻变应原激发诊断结果的变异性和结合主观和客观指标的作用
Yu Zhang,Yu Song,Xu Zhang et al.
Yu Zhang et al.
Background: Nasal allergen challenge (NAC) is currently the only available test to confirm nasal responsiveness to allergens and is a core diagnostic tool for allergic rhinitis. NAC is currently diagnosed by combining exi...
Sebetralstat for On-Demand Treatment of Mucosal Hereditary Angioedema Attacks in KONFIDENT-S [0.03%]
康菲登研究中用于按需治疗遗传性血管水肿发作的塞布特拉司特疗效分析
Jonathan A Bernstein,Emel Aygören-Pürsün,Mauro Cancian et al.
Jonathan A Bernstein et al.
Background: Hereditary angioedema (HAE-C1INH) attacks involving mucosal tissue may progress rapidly and often lead to substantial morbidity. Severe laryngeal attacks can be fatal without prompt administration of on-demand...
Feeding the Skin Barrier: The Impact of Macro- and Micronutrients on Skin Barrier Function [0.03%]
喂养皮肤屏障：宏量和微量营养素对皮肤屏障功能的影响
Klaudia Ryczaj,Burcin Beken,Cezmi Akdis
Klaudia Ryczaj
Background: Skin is the largest organ of the human body, and acts as a fundamental barrier. Beyond its protective role, it serves as a key immune organ, mediating immune surveillance and regulation. Exposure to environmen...
Key Predictors of Adherence to a Mobile Health App for Managing Chronic Spontaneous Urticaria [0.03%]
移动健康应用程序管理慢性自发性荨麻疹依从性的关键预测因素
Hugo Viegas,Bernardo Sousa-Pinto,Rafael José Vieira et al.
Hugo Viegas et al.
Background: Mobile health technologies may improve the management of chronic diseases, such as chronic spontaneous urticaria. However, effectiveness of mHealth tools largely depends on patient adherence, which can be infl...
Delphi Consensus on Attenuated Androgen Use for Long-Term Prophylaxis in Hereditary Angioedema: AURA Project [0.03%]
关于遗传性血管性水肿长期预防中使用雄激素的减量疗法德尔菲共识：AURA项目
Eunice Dias de Castro,Luís Miguel Cardoso,João Jácome de Castro et al.
Eunice Dias de Castro et al.
Background: Danazol and other attenuated androgens (AAs) have been a cornerstone of Hereditary Angioedema (HAE) long-term prophylaxis (LTP) for decades, alongside intravenous plasma-derived C1INH (pdC1INH). Danazol's pote...
Jorge Sánchez,Gabriel Montoya,Ana Caraballo et al.
Jorge Sánchez et al.
Background: Sexual health in patients with atopic dermatitis (AD) remains scarcely studied. Identifying the problematic of sexual health disorders (SHD) in AD and associated factors is important for the design and impleme...
Patient-Reported Outcome Measures as Predictive Tools for Disease Control in Chronic Rhinosinusitis With Nasal Polyps: A Prospective Study [0.03%]
鼻息肉慢性 rhinosinusitis 中患者报告预后测量工具的疾病控制预测作用：一项前瞻性研究
Chen Zhang,Qianqian Zhang,Jiani Chen et al.
Chen Zhang et al.
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impairs the quality of life, and disease control is now considered the primary treatment goal. Although patient-reported outcome measures (PROMs)...