Bifidobacterium animalis subsp. lactis A6 alleviates perennial allergic rhinitis in adults by inhibiting serum total IgE and IL-13: A randomized, double-blind, placebo-controlled trial [0.03%]
一项随机、双盲、安慰剂对照试验：动物乳双歧杆菌亚种乳双歧杆菌A6通过抑制血清总IgE和IL-13缓解成人慢性过敏性鼻炎
Langrun Wang,Shiwen Zhou,Huiyu Chen et al.
Langrun Wang et al.
Objectives: The evidence regarding the efficacy of probiotics in improving allergic rhinitis (AR) remains inconsistent. This study aimed to evaluate the potential effects of Bifidobacterium animalis subsp. lactis A6 (A6) ...
Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling [0.03%]
2型基因表达特征与重症哮喘相关联并提示气道重塑更为严重
Bogdan Jakiela,Karolina Górka,Iwona Gross-Sondej et al.
Bogdan Jakiela et al.
Background: Asthma is a heterogeneous disease with various inflammatory subtypes, including the type-2 (T2) endotype associated with airway eosinophilia. Severe asthma is linked to reduced ventilatory function due to airw...
Associations with food allergy-related psychological distress in a global sample of adults, children and caregivers [0.03%]
全球成人、儿童和照料者食物过敏相关心理压力的关联因素分析
S E M Purser,C J Jones,J L P Protudjer et al.
S E M Purser et al.
Objective: Food allergy (FA) impacts health-related quality of life and mental health. Understanding what variables are associated with psychological distress can help healthcare providers direct patients to appropriate s...
Efficacy and safety of CT-P39, an omalizumab biosimilar, in chronic spontaneous urticaria: 16-week follow-up study [0.03%]
托珠单抗类似物CT-P39治疗慢性自发性荨麻疹的疗效和安全性：24周随访研究
Clive Grattan,Yevgeniya Dytyatkovska,Michał Springer et al.
Clive Grattan et al.
Background: A double-blind, randomized Phase 3 study (NCT04426890) confirmed that CT-P39 and European Union-approved reference omalizumab (ref-OMA) were comparable in terms of efficacy, quality of life (QoL), pharmacokine...
Quality of life in type 2 and non-type 2 endotypes in chronic rhinosinusitis with nasal polyps: A prospective trial [0.03%]
鼻息肉型慢性鼻窦炎两种分型的生活质量研究：一项前瞻性试验
Stijn Bogaert,Elisabeth Rheindorf,Stefan Dazert et al.
Stijn Bogaert et al.
Background: In current clinical practice, primary diffuse chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into two endotypes: type 2 and non-type 2. Previous studies on sinonasal health-related quality of ...
Risk of asthma in individuals with eosinophilic esophagitis: Population-based cohort study with sibling analyses [0.03%]
基于人群的队列研究及同胞分析：嗜酸性食管炎患者哮喘发病风险
Niki Mitselou,Amiko Uchida,Bjorn Roelstraete et al.
Niki Mitselou et al.
Introduction: There are limited data on the relationship between eosinophilic esophagitis (EoE) and asthma. We aimed to assess the risk of asthma in EoE patients compared with matched controls and siblings. ...
Association between telomere length and atopic dermatitis among school-age children [0.03%]
学龄儿童端粒长度与特应性皮炎的相关性研究
Hsin-Yi Huang,Kun-Hua Sheen,Chi-Yen Hung et al.
Hsin-Yi Huang et al.
Background: Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population-based case-control study aimed to investigate the a...
All change, 2025 [0.03%]
变局二零二五
Clive Grattan,Jean Bousquet
Clive Grattan
The diagnosis of lipid transfer protein allergy-Discriminating between sensitisation and allergy [0.03%]
脂质转运蛋白过敏的诊断-区分致敏和过敏
B Olivieri,G Scadding,I J Skypala
B Olivieri
Background: Sensitisation to Lipid Transfer Proteins (LTP), usually ascertained by undertaking a test to the peach LTP allergen Pru p 3, is common but does not always indicate LTP allergy. Improving the diagnostic process...
Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure [0.03%]
KIT p.D816V阳性患者进行毒液免疫治疗期间发生系统性不良事件的风险高及疗效不佳
Ajda Demšar Luzar,Jakob Otorepec,Mitja Košnik et al.
Ajda Demšar Luzar et al.
Background: Recent studies have highlighted the importance of routine screening for the somatic missense KIT p.D816V variant in peripheral blood leukocytes (PBL), and its association with severe sting anaphylaxis. Our stu...