Long-term cure of soft tissue sarcoma with pegylated-liposomal doxorubicin after doxorubicin and ifosfamide failure [0.03%]
多柔比星和异环磷酰胺治疗失败后采用脂质体多柔比星治疗软组织肉瘤并获得长期治愈
Malvi Savani,Paari Murugan,Keith M Skubitz
Malvi Savani
Background: Doxorubicin is one of the most active drugs available for the treatment of sarcoma. Pegylated-liposomal doxorubicin (PLD) is a formulation of doxorubicin in which the doxorubicin is encapsulated in liposomes c...
Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment [0.03%]
骨盆去分化软骨肉瘤的临床预后和治疗现状分析
Johnathan R Lex,Scott Evans,Jonathan D Stevenson et al.
Johnathan R Lex et al.
Background: Dedifferentiated chondrosarcomas (CS) are a high-grade variant of CS that confers a 5-year survival of around 10-24%. Dedifferentiated CS arising from the pelvis confers an even worse prognosis. ...
Luca Paoluzzi,Munir Ghesani
Luca Paoluzzi
Background: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant mesenchymal neoplasm of uncertain differentiation characterized by rearrangements of the NR4A3 gene. EMC often affects adults around the age of 50 ...
Descending thoracic aortic aneurysm revealing metastasis of a soft tissue fibrosarcoma: a case report and review of the literature [0.03%]
软组织纤维肉瘤转移性降主动脉动脉瘤一例及文献复习
Clotilde Delerce,Olivia Bailly,Amine Bouhamama et al.
Clotilde Delerce et al.
Background: Review of the first documented case of aortic wall metastasis from a limb sarcoma. Case presentation: In a 56-year-old woma...
A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas [0.03%]
替西罗莫司联合多柔比星脂质体治疗骨及软组织肉瘤患者的II期临床研究
Matteo M Trucco,Christian F Meyer,Katherine A Thornton et al.
Matteo M Trucco et al.
Background: Relapsed and refractory sarcomas continue to have poor survival rates. The cancer stem cell (CSC) theory provides a tractable explanation for the observation that recurrences occur despite dramatic responses t...
Preoperative radiotherapy of soft-tissue sarcomas: surgical and radiologic parameters associated with local control and survival [0.03%]
术前软组织肉瘤放射治疗的局部控制和生存影响因素的研究
Panagiotis Tsagozis,Otte Brosjö,Mikael Skorpil
Panagiotis Tsagozis
Background: Preoperative radiotherapy is often used to facilitate excision of soft-tissue sarcomas. We aimed define factors that affect local tumour control and patient survival. ...
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint [0.03%]
骨和关节良恶性疾病中的periostin表达
Jennifer M Brown,Akiro Mantoku,Afsie Sabokbar et al.
Jennifer M Brown et al.
Background: Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, w...
Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis [0.03%]
低级别中央成纤维细胞骨肉瘤可通过基因分析与其类似病变——硬化性骨纤维瘤鉴别开来
Wangzhao Song,Eva van den Berg,Thomas C Kwee et al.
Wangzhao Song et al.
Background: We studied two cases of rare fibrous bone tumors, namely desmoplastic fibroma (DF) and low-grade central osteosarcoma (LGCOS) resembling desmoplastic fibroma (DF-like LGCOS). As the clinical presentation, imag...
Retrospective audit of 957 consecutive 18F-FDG PET-CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma [0.03%]
957例连续18F-FDG PET-CT扫描的回顾性分析及其与骨和软组织肉瘤不同组织学亚型患者493例CT和MRI检查结果的比较
Ruth E Macpherson,Sarah Pratap,Helen Tyrrell et al.
Ruth E Macpherson et al.
Background: The use of 18F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-di...
Jie Xu,Lu Xie,Wei Guo
Jie Xu
New treatment options for advanced osteosarcoma have remained limited. The platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway plays an important role in the development and metastasis of osteosarco...