Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis [0.03%]
组蛋白去乙酰化酶抑制剂提高尤文肉瘤中NKG2D配体的表达并增强自然杀伤细胞介导的溶解作用
Dagmar Berghuis,Marco W Schilham,Hanneke I Vos et al.
Dagmar Berghuis et al.
Background: Ewing sarcoma patients have a poor prognosis despite multimodal therapy. Integration of combination immunotherapeutic strategies into first-/second-line regimens represents promising treatment options, particu...
The clinical use of biomarkers as prognostic factors in Ewing sarcoma [0.03%]
生物标志物在 ewing 肉瘤预后中的临床应用
Annmeik M van Maldegem,Pancras Cw Hogendoorn,Andrew B Hassan
Annmeik M van Maldegem
Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of the 35% who develop recurrence. ...
Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours [0.03%]
尤因肉瘤/原始神经外胚层肿瘤的分子发病机制和靶向治疗学进展
Fergal C Kelleher,David M Thomas
Fergal C Kelleher
Background: Ewing sarcoma/PNET is managed with treatment paradigms involving combinations of chemotherapy, surgery, and sometimes radiation. Although the 5-year survival rate of non-metastatic disease approaches 70%, thos...
Comprehensive analysis of published phase I/II clinical trials between 1990-2010 in osteosarcoma and Ewing sarcoma confirms limited outcomes and need for translational investment [0.03%]
对1990年至2010年期间骨肉瘤和尤因肉瘤发表的I/II期临床试验进行综合分析，证实了成果有限并需要进行转化投资
Annemiek M van Maldegem,Aparna Bhosale,Hans J Gelderblom et al.
Annemiek M van Maldegem et al.
Background: High grade primary bone sarcomas are rare cancers that affect mostly children and young adults. Osteosarcoma and Ewing sarcoma are the most common histological subtypes in this age group, with current multimod...
Fibrosarcomatous changes and expression of CD34+ and apolipoprotein-D in dermatofibrosarcoma protuberans [0.03%]
关于隆突性皮肤纤维肉瘤的细胞角蛋白、CD34及载脂蛋白D的变化及其意义
Emanuela Palmerini,Marco Gambarotti,Eric L Staals et al.
Emanuela Palmerini et al.
Background: Dermatofibrosarcoma protuberans (DFSP) is a relatively common soft-tissue tumor. A more aggressive appearing fibrosarcoma may arise in DFSP, changing its biological behavior. CD34 and apolipoprotein-D are high...
Paratesticular desmoplastic small round cell tumour: an unusual tumour with an unusual fusion; cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH [0.03%]
阴囊内并发性细胞灶小圆细胞肿瘤的细胞遗传学和分子生物学分析联合了RT-PCR及COBRA-FISH技术
Vincent Pm Cliteur,Károly Szuhai,Hans J Baelde et al.
Vincent Pm Cliteur et al.
Desmoplastic small round cell tumour is a rare malignant tumour with a male to female ratio of 4:1. It manifests mostly at serosal sites. Here we present a case of a 28-year-old male patient, who presented with a fast growing paratesticular...
Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma [0.03%]
多形性脂肪肉瘤一线使用阿霉素和异环磷酰胺的效果
Daniela Katz,Piyaporn Boonsirikamchai,Haeson Choi et al.
Daniela Katz et al.
Background: Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been c...