Andrew G Muntean
Andrew G Muntean
Advances in our understanding of the genetic determinants of leukemia have translated to better treatment options and improved survival of patients with acute myeloid and acute lymphoid leukemia. However, some leukemias, such as those beari...
Juliana Benito,Zhihong Zeng,Marina Konopleva et al.
Juliana Benito et al.
The bone marrow (BM) microenvironment regulates survival and maintenance of normal hematopoietic stem cells. Within the endosteal niche, hypoxia has an essential role in maintenance of the primitive quiescent hematopoietic stem cell. We and...
Acute myeloid leukemia: potential for new therapeutic approaches targeting mRNA translation pathways [0.03%]
急性髓系白血病：针对mRNA翻译途径的新治疗策略的潜力
Jessica K Altman,Leonidas C Platanias
Jessica K Altman
Despite advances in molecular research related to acute myeloid leukemia (AML) and a better understanding of the mechanisms of leukemogenesis and pathophysiology of the disease, the pharmacological agents used in the treatment of AML have r...
New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation [0.03%]
allo-HSCT后微小残留病的新对策
Lindsay Am Rein,Anthony D Sung,David A Rizzieri
Lindsay Am Rein
Minimal residual disease (MRD) is a complex topic that has been studied extensively in hematologic malignancies given its clinical implications related to prognosis. However, methods to monitor and treat MRD, especially after stem cell tran...
Current approaches to the initial treatment of symptomatic multiple myeloma [0.03%]
当前关于有症状多发性骨髓瘤初始治疗的手段
Jagoda K Jasielec,Andrzej J Jakubowiak
Jagoda K Jasielec
The treatment of newly diagnosed multiple myeloma has dramatically changed since the emergence of proteasome inhibitors and immunomodulatory drugs. Front-line combination regimens incorporating novel drugs such as thalidomide, bortezomib an...
Qiushi Chen,Turgay Ayer,Loretta J Nastoupil et al.
Qiushi Chen et al.
Follicular lymphoma (FL) can vary markedly in its initial presentation, and no single standard approach for its initial management has been adopted. Available options for the initial management of FL include watchful waiting, radiation, sin...