Diagnostic and treatment of adult Philadelphia chromosome-positive acute lymphoblastic leukemia [0.03%]
成人费城染色体阳性急性淋巴细胞白血病的诊断和治疗
Xavier Thomas,Maël Heiblig
Xavier Thomas
The outcome of adult patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has improved substantially with the introduction of tyrosine kinase inhibitors (TKIs). TKIs are now integral components of therapy ...
Five-year direct costs of acute lymphoblastic leukemia pediatric patients undergoing allogeneic stem cell transplant [0.03%]
急性淋巴细胞白血病儿童患者接受异基因干细胞移植的五年直接成本支出分析
Richard T Maziarz,Annie Guérin,Geneviève Gauthier et al.
Richard T Maziarz et al.
Aim: To assess the 5-year healthcare resource utilization (HRU) and direct payer costs following allogeneic hematopoietic stem cell transplants (HSCTs) in acute lymphoblastic leukemia pediatric patients using data from tw...
Cancer treatment in the extreme elderly: case study of a 100-year-old lymphoma patient [0.03%]
百岁淋巴瘤患者的癌症治疗——一例研究报告
Peter J Gilbar,Howard Mutsando,Joshua P Richmond et al.
Peter J Gilbar et al.
Limited data are available on the treatment of older adults with cancer. Comorbidities may preclude the administration of effective therapies, particularly in the extreme elderly. Comprehensive geriatric assessment can identify specific wea...
Current treatment options in elderly patients with chronic lymphocytic leukemia [0.03%]
慢性淋巴细胞白血病老年患者当前治疗选择
Stefano Molica
Stefano Molica
Targeting B-cell receptor signaling in leukemia and lymphoma: how and why? [0.03%]
靶向白血病和淋巴瘤中的B细胞受体信号通路：如何以及为何？
John C Allen,Fatima Talab,Joseph R Slupsky
John C Allen
B-lymphocytes are dependent on B-cell receptor (BCR) signaling for the constant maintenance of their physiological function, and in many B-cell malignancies this signaling pathway is prone to aberrant activation. This understanding has led ...
Dielectrophoretic recovery of DNA from plasma for the identification of chronic lymphocytic leukemia point mutations [0.03%]
等电泳法从血浆中提取DNA以识别慢性淋巴细胞白血病点突变
Sareh Manouchehri,Stuart Ibsen,Jennifer Wright et al.
Sareh Manouchehri et al.
Aim: Circulating cell free (ccf) DNA contains information about mutations affecting chronic lymphocytic leukemia (CLL). The complexity of isolating DNA from plasma inhibits the development of point-of-care diagnostics. He...
Erythrocyte encapsulated l-asparaginase (GRASPA) in acute leukemia [0.03%]
红细胞包裹l-天冬氨酶（GRASPA）在急性白血病中的应用
Xavier Thomas,Caroline Le Jeune
Xavier Thomas
l-asparaginase, an enzyme originally derived from Escherichia coli, represents a major drug in the treatment of acute lymphoblastic leukemia. However, the occurrence of major adverse effects often leads to early withdrawal of the enzyme. Ma...
Propylene glycol-free melphalan as conditioning regimen for autologous transplantation in myeloma [0.03%]
不用丙二醇的美法仑作为自体移植治疗多发性骨髓瘤的预处理方案
Omar S Aljitawi,Parameswaran Hari
Omar S Aljitawi
High-dose melphalan has been the drug of choice for preparative regimens for autologous stem cell transplantation in multiple myeloma. Propylene-free melphalan (Evomela™) is a newer formulation of melphalan, which incorporates Captisol® t...
Survivors at risk: Hodgkin lymphoma survivors at high risk of second cancers [0.03%]
霍奇金淋巴瘤幸存者患第二癌症的风险较高
Amit Sud
Amit Sud
Amit Sud speaks to Sebastian Dennis-Beron, Commissioning Editor: Amit Sud is a clinical research fellow in Hematology at the Institute of Cancer Research, UK. He undertook his undergraduate medical training at the University of Manchester, ...
Approaches for the prevention of graft-versus-host disease following hematopoietic cell transplantation [0.03%]
造血干细胞移植后预防移植物抗宿主病的方法
Erin Gatza,Sung Won Choi
Erin Gatza
Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic option for malignant and non-malignant diseases, but the more widespread application of the therapy remains limited by the occurrence of graft versus host disea...